ISSN: 2573-4555

Journal of Traditional Medicine & Clinical Naturopathy
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  • Research Article   
  • J Tradit Med Clin Natur ,
  • DOI: 10.4172/2573-4555.1000286

In vivo Studies of Anti-Inflammatory and Anti-Diabetic Activities of the Methanolic Extract of Pilea microphylla on Experimental Mice

Imtiaj Hossain Chowdhury, SM Riajul Wahab*, Ohidul Islam, Mahnaz Shiara, Fahim Faysal, Devaroti Bhattacherjee and Semanto Ray
Department of Pharmacy, Bangladesh University, Dhaka-1207, Bangladesh
*Corresponding Author : SM Riajul Wahab, Department of Pharmacy, Bangladesh University, Dhaka-1207, Bangladesh, Email: riajulwahab@yahoo.com

Received Date: Jun 24, 2020 / Accepted Date: Jul 09, 2020 / Published Date: Jul 16, 2020

Abstract

Introduction: Ethnopharmacological relevance: Pilea microphylla is an important medicinal plant belonging to family Urticeaceae. This plant is used in traditional medicine to balance insulin levels and cure diabetes. This herb is beneficial in treating disorder related to breathing problem including asthma.

Aim of the study: The aim of the present study was to assess the in vivo anti-inflammatory activity and Antidiabetic activity of methanolic extracts of Pilea microphylla.

Materials and methods: The anti-inflammatory effect of the extracts was evaluated on paw edema in mice induced by carrageenan and the anti-diabetic activity was determined by oral glucose tolerance test (OGTT).

Results: In the present study the anti-inflammatory effect was observed of methanol extract in doses of 250 mg/kg and 500 mg/kg and the results were 74.18% and 72.17% inhibition of paw edema respectively compared to the standard drug Diclofenac-Na 80.42% inhibition of paw edema. The anti-diabetic effect was observed of methanol extract in doses of 250 mg/kg and 500 mg/kg and the results were 56.44% and 62.26% inhibition of paw edema respectively compared to the standard drug Metformin hydrochloride 78.05% inhibition of paw edema.

Conclusion: These findings suggest the use of Pilea microphylla as therapeutic agents to treat diabetes and inflammation as an alternative option of synthetic drugs particularly among poor people of developing countries.

Keywords: Pilea microphylla; Carrageenan anti-inflammatory activity; Anti-diabetic activity; OGTT

Citation: Chowdhury IH, Wahab SMR, Islam O, Shiara M, Faysal F, et al. (2020) In vivo Studies of Anti-Inflammatory and Anti-Diabetic Activities of the Methanolic Extract of Pilea microphylla on Experimental Mice. J Tradit Med Clin Natur 9: 286. Doi: 10.4172/2573-4555.1000286

Copyright: © 2020 Chowdary IH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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