Abstract

Vascular growth factor is a hallmark of cancer, and associations between genetic polymorphisms and neoplasia have been extensively studied in the adult population. Regarding the neonatal population, few studies have attempted to clarify the association of VEGF gene polymorphisms with neonatal pathologies, especially pathologies associated with late complications. Our aim was to review the literature on VEGF polymorphisms and neonatal morbidity. Narrative synthesis of results was performed using pre-determined subheadings (low birth weight or preterm infants, heart disease, lung disease, eye disease, brain disease, gastrointestinal disease). VEGF polymorphisms appear to be associated with neonatal pathologies. The involvement of VEGF and VEGF polymorphisms has been demonstrated in retinopathy of prematurity.