alexa Involvement of Oxidative Stress and Nitric Oxide in Fibromyalgia Pathophysiology: A Relationship to be Elucidated

Fibromyalgia: Open Access
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Review Article

Involvement of Oxidative Stress and Nitric Oxide in Fibromyalgia Pathophysiology: A Relationship to be Elucidated

Andrei Pereira Pernambuco1,2,3*, Luana Pereira Leite Schetino3,4, Luciana de Souza Cota Carvalho3,5 and Débora d’Ávila Reis3

1University Center Formiga, MG. Avenida Doutor Arnaldo Senna , 328. Red Water - Formiga, Minas Gerais, Brazil

2University of Itauna, MG. MG highway , 431 Km 45 , s / n - Green Campus, Itauna , Minas Gerais, Brazil

3Institute of Biological Sciences, Federal University of Minas Gerais. Avenida Presidente Antônio Carlos , 6627 - Pampulha , Belo Horizonte , Minas Gerais, Brazil

4Federal University of the Jequitinhonha Valley and Mucuri . Campus I - Diamantina , Minas Gerais, Brazil

5Hospital Mater Dei. Avenida do Contorno, 9000 - Barro Preto, Belo Horizonte - Minas Gerais, Brazil

*Corresponding Author:
Andrei Pereira Pernambuco
Rua Araxá – 206, Residencial Morro do Sol
Itaúna, Minas Gerais, Brazil
Tel: +55 (37) 3242-1477
E-mail: [email protected]

Received date: December 30, 2015 Accepted date: February 28, 2016 Published date: March 02, 2016

Citation: Pernambuco AP, Schetino LPL, Carvalho LSC and Reis DA (2016) Involvement of Oxidative Stress and Nitric Oxide in Fibromyalgia Pathophysiology: A Relationship to be Elucidated. Fibrom Open Access 1:105. doi:10.4172/foa.1000105

Copyright: © 2016 Pernambuco AP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Fibromyalgia (FM) is a rheumatic syndrome characterized by chronic widespread pain that is often associated with other signs and symptoms such as sleep disturbances, headache, fatigue and morning stiffness. To date, the pathogenesis of fibromyalgia is unknown, several studies have been conducted in or to clarify it. Genetic and psychological abnormalities, dysfunctions of the central nervous system, endocrine and immunological disorders as well as abnormalities of the peripheral microcirculation have been identified in FM patients, demonstrating that many factors may interact in the pathogenesis of this condition. Recent research suggest that oxidative stress (OS) and nitric oxide (NO) may be directly involved in the pathophysiology of this syndrome, however, the mechanism by which such interference takes place is not fully elucidated. Currently, there is an increasing number of research papers that demonstrate both, altered concentrations of oxidants resulting from the OS mechanism, and antioxidants as for example NO among patients with FM. Thus, the purpose of this review was to gather and organize part of the information available about the participation of NO in the OS in the symptoms of FM.


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