ISSN: 2576-3881

Journal of Cytokine Biology
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Mini Review   
  • J Cytokine Biol 2022, Vol 7(4): 416
  • DOI: 10.4162/2576-3881.1000416

Macrophages Play a Critical Role in Bone Conformation and Destruction

Qiaoli Gu*
Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China
*Corresponding Author : Qiaoli Gu, Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China, Email: QiaoliGu@gmail.com

Received Date: Jul 02, 2022 / Published Date: Jul 28, 2022

Abstract

Alternately actuated macrophages (M2 macrophages) play key places in the repression of Th1 cell responses and the unity of towel form. Still, recent studies have shown that M2 macrophages have capabilities to produce high levels of proinflammatory cytokines similar as IL- 1β, IL- 6, and TNF- α, suggesting that M2 macrophages may complicate inflammation in some settings. We’ve also shown that suppressor of cytokine signalling- 3( SOCS3), a member of SOCS family proteins that are cytokine- inducible negative controllers of the JAK/ STAT signalling pathways, is largely and preferentially expressed in M2 macrophages in hapten- convinced CHS and that SOCS3 expressed in M2 macrophages is involved in the attenuation of CHS by suppressing MMP12 product. These findings emphasize the significance of M2 macrophage- deduced MMP12 in the development of CHS, and suggest that inhibition of M2 macrophages or MMP12 could be a implicit remedial strategy for the treatment of antipathetic contact dermatitis [1-2].

Citation: Gu Q (2022) Macrophages Play a Critical Role in Bone Conformation and Destruction. J Cytokine Biol 7: 416. Doi: 10.4162/2576-3881.1000416

Copyright: © 2022 Gu Q. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top