Abstract

Metabolic syndrome, a global health challenge, shows increasing prevalence and regional disparities. Its pathophysiology involves insulin resistance and chronic inflammation. Effective management encompasses evolving diagnostic criteria, crucial lifestyle modifications like tailored diets and physical activity, and emerging pharmacological targets. Dietary fatty acids, the Mediterranean diet, and gut microbiota’s role in dysbiosis offer insights into prevention and therapy. This synthesis underscores the need for comprehensive strategies, integrating research on mechanisms and interventions to address this complex multifactorial condition and its public health burden.