Abstract

Deep Brain Stimulation (DBS) has emerged as a pivotal treatment for motor symptoms in Parkinson’s disease (PD). However, its effects on non-motor symptoms (NMS) are varied and less predictable. Recent advancements in neuroimaging, particularly in understanding brain microstructure, offer promising insights into forecasting these non-motor outcomes. This article explores the role of brain microstructure in predicting non-motor responses to DBS in PD, examining how changes in white matter integrity and connectivity might influence cognitive, emotional, and autonomic functions post-surgery