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ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Research Article   
  • J Clin Exp Pathol 2016, Vol 6(6): 299
  • DOI: 10.4172/2161-0681.1000299

Missed Diagnosis of Cancer in Critically Ill Patients: A Single-Center Experience

Berlot G1*, Calderan C1, Moro V1, Bussani R2 and Zandonà L2
1Department of Anaesthesia and Intensive Care Medicine, University of Trieste, Trieste, Italy
2Department of Pathology, University of Trieste, Trieste, Italy
*Corresponding Author : Berlot G, Department of Anaesthesia and Intensive Care, Cattinara Hospital, Strada di Fiume 447, Trieste, 34149, Italy, Tel: +39040-3994540; +39040-912278, Email: [email protected]

Received Date: Nov 15, 2016 / Accepted Date: Nov 19, 2016 / Published Date: Nov 22, 2016


Purpose and methods: In order to evaluate the rate of missed diagnoses (MD) of tumors in critically ill patients died in our Intensive Care Unit (ICU) and correlate them with the outcome, all the autopsy records from January 1st, 1996 and December 31st, 2014 have been reviewed. When the tumor was not diagnosed during the admission but discovered only at the post-mortem examination, the effect of the MD on the outcome was classified according to the Goldman’s criteria.

Results: A total of, 1045 autopsies were examined; a solid or hematological cancer was discovered in 74 cases (7%, 50 M, 24 F, age 75.5, IQR 29-90 years). Major discrepancies occurred in 42 patients, but only in one of them (2.4%) a class 1 error was identified; in the other cases the MD did not influence the outcome (class 2 errors) due to the underlying conditions determining the ICU admission and/or the very short length of stay in the ICU; for another 32 patients the MD were considered without clinical relevance.

Conclusions: In our experience, autopsy remains an extremely valuable tool to detect MD and to improve the clinical and diagnostic procedures.

Keywords: Autopsy; Missed diagnosis; Intensive care unit; Tumors

Citation: Berlot G, Calderan C, Moro V, Bussani R, Zandonà L (2016) Missed Diagnosis of Cancer in Critically Ill Patients: A Single-Center Experience. J Clin Exp Pathol 6:299. Doi: 10.4172/2161-0681.1000299

Copyright: © 2016 Berlot G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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