Abstract

Mitochondrial dysfunction is a central pathological mechanism underlying a broad spectrum of human diseases, including chronic inflammatory, cardiovascular, neurodegenerative, metabolic, and liver disorders, alongside aging and cancer. This cellular impairment involves key aspects like impaired bioenergetics, increased oxidative stress, and dysfunctional mitochondrial quality control. These contribute significantly to inflammation, tissue damage, and cellular senescence. Consequently, targeting mitochondrial health represents a highly promising therapeutic strategy to combat these diverse conditions. This review highlights the pervasive role of mitochondrial dysfunction and its substantial potential as a crucial therapeutic avenue