ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Review Article   
  • J Clin Exp Pathol 2018, Vol 8(1): 334
  • DOI: 10.4172/2161-0681.1000334

Mitochondrial Dysfunction Signature in Diabetic Vascular Endothelium

Lucia-Doina Popov*
Nicolae Simionescu Institute of Cellular Biology and Pathology of the Romanian Academy, , 8, B. P. Hasdeu Street, Bucharest, 050568, Romania
*Corresponding Author : Lucia-Doina Popov, Nicolae Simionescu Institute of Cellular Biology and Pathology of the Romanian Academy 8, B. P. Hasdeu Street, Bucharest, 050568, Romania, Tel: +40213192737, Fax: +40213194519, Email: doina.popov@icbp.ro

Received Date: Dec 18, 2017 / Accepted Date: Jan 09, 2018 / Published Date: Jan 12, 2018

Abstract

Mitochondrial dysfunction/malfunction is an important risk factor for the onset and progression of endothelial cells dysfunction, a key contributor to diabetes mellitus associated cardiovascular disease. The topics discussed here are: (i) The regulatory role of mitochondrial ROS in normal, healthy vascular endothelium, (ii) The adverse alteration of mitochondrial function in diabetes-related endothelial dysfunction, (iii) The endeavors towards correction of mitochondrial malfunction in dysfunctional endothelium, (iv) The key points of mitochondria-targeted interventions in diabetic patients, and (v) The pending, incompletely understood issues that open new basic research directions and may conduct to innovative therapeutic strategies in diabetes.

Keywords: Endothelial dysfunction; Mitochondrial dynamics; Mitochondrial medicine

Citation: Doina Popov L (2018) Mitochondrial Dysfunction Signature in Diabetic Vascular Endothelium. J Clin Exp Pathol 8: 334. Doi: 10.4172/2161-0681.1000334

Copyright: ©2017 Doina Popov L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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