Mitochondrial Dysfunction Signature in Diabetic Vascular Endothelium
Received Date: Dec 18, 2017 / Accepted Date: Jan 09, 2018 / Published Date: Jan 12, 2018
Abstract
Mitochondrial dysfunction/malfunction is an important risk factor for the onset and progression of endothelial cells dysfunction, a key contributor to diabetes mellitus associated cardiovascular disease. The topics discussed here are: (i) The regulatory role of mitochondrial ROS in normal, healthy vascular endothelium, (ii) The adverse alteration of mitochondrial function in diabetes-related endothelial dysfunction, (iii) The endeavors towards correction of mitochondrial malfunction in dysfunctional endothelium, (iv) The key points of mitochondria-targeted interventions in diabetic patients, and (v) The pending, incompletely understood issues that open new basic research directions and may conduct to innovative therapeutic strategies in diabetes.
Keywords: Endothelial dysfunction; Mitochondrial dynamics; Mitochondrial medicine
Citation: Doina Popov L (2018) Mitochondrial Dysfunction Signature in Diabetic Vascular Endothelium. J Clin Exp Pathol 8: 334. Doi: 10.4172/2161-0681.1000334
Copyright: ©2017 Doina Popov L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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