Abstract

Molecular pharmaceutics plays a crucial role in optimizing drug delivery and therapeutic outcomes. It enhances therapeutic drug monitoring for personalized patient care, minimizing adverse effects, especially for narrow therapeutic window drugs. The field advances mRNA vaccine formulations through stable lipid nanoparticle systems, and addresses complex delivery challenges for biologics, nucleic acids in gene therapy, and CRISPR/Cas9 systems, ensuring targeted action. It also explores innovative strategies for oral delivery of peptides, proteins, and mRNA therapeutics, overcoming bioavailability barriers. Additionally, molecular pharmaceutics significantly contributes to designing advanced delivery systems for cancer immunotherapy, boosting efficacy and reducing toxicity. This multidisciplinary field is central to contemporary pharmaceutical innovation.