Neutrophil CD64 Expression in Crohnâ��s Disease following Anti-TNF-�± Therapy
Received Date: Sep 29, 2017 / Accepted Date: Oct 09, 2017 / Published Date: Oct 17, 2017
Abstract
Objective: Anti-TNF-α therapy is an effective therapy for Crohn’s disease (CD). Thus anti-TNF-α therapy may alter CD64 expression, one of the Fc receptors for IgG, in CD. We investigated CD64 expression on neutrophils before and after treatment with anti-TNF-α therapy in CD.
Methods: A total of 11 patients with active CD treated with anti-TNFα antibodies were enrolled. The severity of CD was assessed with the CD activity index (CDAI). Peripheral venous blood was obtained before and 2 weeks after the initial administration of anti-TNF-α antibody. CD64 expression on neutrophils was measured by FACS analysis of whole blood samples.
Results: CDAI, C-reactive protein value and CD64 expression decreased significantly after anti-TNF-α therapy. Both prior to and after anti-TNF treatment, there was a significant and positive correlation between CD64 expression and CDAI or CRP. Similarly, there was a significant and negative correlation between CD64 and albumin value.
Conclusion: Anti-TNF-α therapy suppresses CD64 expression of neutrophils, which may account for the mechanism underlying the efficacy of the medication in CD.
Keywords: CD64; Crohn’s disease; Anti-TNF-α therapy; Infliximab
Citation: Chiba T, Endo M, Miura S, Hayashi Y, Asakura Y, et al. (2017) Neutrophil CD64 Expression in Crohn’s Disease following Anti-TNF-α Therapy. J Cytokine Biol 2: 119. Doi: 10.4172/2576-3881.1000119
Copyright: © 2017 Chiba T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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