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Novel Drug Delivery System: Liquid Solid Compacts | OMICS International| Abstract
ISSN: 2329-9053

Journal of Molecular Pharmaceutics & Organic Process Research
Open Access

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  • Review Article   
  • J Mol Pharm Org Process Res 2013, Vol 1(3): 108
  • DOI: 10.4172/2329-9053.1000108

Novel Drug Delivery System: Liquid Solid Compacts

Manasa Gangotri Peddi,*
Department of Pharmaceutics, St. Paul’s College of Pharmacy, , Turakayamjal, Andhra Pradesh, India
*Corresponding Author : Manasa Gangotri Peddi, Post Graduate of Pharmaceutics, St. Paul's College of Pharmacy, Turakayamjal, Andhra Pradesh, India, Tel: +91-9490004072, Email: [email protected]

Received Date: Oct 27, 2013 / Accepted Date: Nov 19, 2013 / Published Date: Nov 29, 2013

Abstract

The “Liquid-solid” technique is a novel and capable addition towards such an aims for solubility enhancement and dissolution improvement, thereby it increases the bioavailability. It contains liquid medications in powdered form. This technique is an efficient method for formulating water insoluble and water soluble drugs. This technique is based upon the admixture of drug loaded solutions with appropriate carrier and coating materials. The use of non-volatile solvent causes improved wettability and ensures molecular dispersion of drug in the formulation and leads to enhance solubility. By using hydrophobic carriers (non-volatile solvents) one can modify release (sustained release) of drugs by this technique. Liquid-solid system is characterized by flow behavior, wettability, powder bed hydrophilicity, saturation solubility, drug content, differential scanning calorimetry, Fourier transform infra red spectroscopy, powder X-ray diffraction, scanning electron microscopy, in vitro release and in vivo evaluation. By using this technique, solubility and dissolution rate can be improved, sustained drug delivery systems be developed for the water soluble drugs.

Keywords: Bioavailability; Solid dispersions; Oleophilic medication

Citation: Peddi MG (2013) Novel Drug Delivery System: Liquid Solid Compacts J Mol Pharm Org Process Res 1: 108 Doi: 10.4172/2329-9053.1000108

Copyright: ©2013 Peddi MG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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