Abstract

When designing effective biomaterials or drug carriers for cancer treatment, N-rich organic materials with nanoscale porosities and polyphenolic moieties in their building networks pose a significant challenge.TrzTFPPOP, a novel polyphenolic porous organic polymer based on triazine, was used to investigate the possibility of in vitro anticancer activity on the human colorectal carcinoma (HCT 116) cell line.The functionalized organic material (-OH, -NH, and -C=N) had a BET surface area of 2140 m2 g1 and hierarchical porosity (micropores and mesopores). It also caused apoptosis, which made it possible for the DNA damage pathway, which is controlled by p53, to kill colon cancer cells with high efficiency.The MTT assay yielded results of 1.24, 3.25, and 5.25 g/mL, respectively, for the IC₃₀, IC₅₀, and IC₇₀.