Nucleic Acid Based Biosensors for Clinical Applications | OMICS International| Abstract
ISSN: 2090-4967

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  • Review Article   
  • Biosens J 2013 2:104,
  • DOI: 10.4172/2090-4967.1000104

Nucleic Acid Based Biosensors for Clinical Applications

Utpal Bora1,2*, Arghya Sett1 and Deepika Singh1
1Department of Biotechnology, Bioengineering Research Laboratory, Indian Institute of Technology Guwahati, Guwahati, Assam-781039, India
2Mugagen Laboratories Pvt. Ltd., Technology Incubation Centre, Indian Institute of Technology Guwahati, Guwahati, Assam-781039, India
*Corresponding Author : Utpal Bora, Department of Biotechnology, Bioengineering Research Laboratory,Indian Institute of Technology Guwahati, Guwahati, Assam-781039, India, Tel: 913612582215, Fax: +913612582249, Email: [email protected]

Received Date: Sep 12, 2013 / Accepted Date: Oct 25, 2013 / Published Date: Nov 04, 2013


Biosensors are analytical tools which have applications in diverse fields like diagnostics, disease monitoring etc. Since last few decades, nucleic acid based analytics have gained much interest in detection and monitoring of various clinical manifestations. Nucleic acid based biosensors (NABs) are preferred choice due to their high sensitivity and selectivity. Novel synthetic probes (PNA, Aptamer) have been exploited to fabricate point-of-care NABs. Due to flexible and low-cost fabrication, they are evolving as rapid and reliable tools in clinical diagnostics market. In this review, we focus on different transducer platform (Optical, Electrochemical, Piezoelectrical) based NABs which have been implemented to detect broad spectrum of metabolic and infectious diseases. A few commercialized NAB products are also summarized.

Keywords: Biosensors, Nucleic Acid Biosensors (NABs, Clinical applications

Citation: Bora U, Sett A, Singh D (2013) Nucleic Acid Based Biosensors for Clinical Applications. Biosens J 2:104. Doi: 10.4172/2090-4967.1000104

Copyright: © 2013 Bora U, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.