Abstract

Deossification, the core of osteoporosis, involves an imbalance between bone formation and resorption. This comprehensive overview highlights various contributing factors including chronic inflammation, genetic predispositions, diabetes, age, and nutritional deficiencies. It also covers the significant roles of the bone marrow microenvironment and osteocytes, alongside the impact of physical activity and certain medications. Diagnostic advancements and a spectrum of therapeutic approaches are discussed, all aiming to preserve skeletal integrity and prevent fragility fractures, underscoring a multi-faceted approach to bone health management.