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Outbreak of SARS-CoV-2 Associated with Omicron Variant Infection in Healthcare Workers in Japan | OMICS International| Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Short Communication   
  • J Infect Dis Ther,
  • DOI: 10.4172/2332-0877.1000503

Outbreak of SARS-CoV-2 Associated with Omicron Variant Infection in Healthcare Workers in Japan

Shinya Otsuka1,2, Kei Hiraoka1,2*, Masato Suzuoki1, Hideki Ujiie2, Tatsuya Kato2, Isao Yokota3, Kazuya Yonezawa4, Keiji Oguma5, Nozomu Iwashiro1, Mototsugu Kato6 and Masanori Ohara1
1Department of Surgery, National Hospital Organization (NHO) Hakodate National Hospital, Hakodate, Hokkaido, Japan
2Department of Thoracic Surgery, Hokkaido University, Sapporo, Hokkaido, Japan
3Department of Biostatistics, Hokkaido University, Sapporo, Hokkaido, Japan
4Department of Cardiovascular Medicine, NHO Hakodate National Hospital, Hakodate, Hokkaido, Japan
5Department of Clinical Laboratory, NHO Hakodate National Hospital, Hakodate, Hokkaido, Japan
6Department of Gastroenterology, NHO Hakodate National Hospital, Hakodate, Hokkaido, Japan
*Corresponding Author : Dr. Kei Hiraoka, Department of Surgery, National Hospital Organization (NHO) Hakodate National Hospital, Hakodate, Hokkaido, Japan, Email: hiraoka@med.hokudai.ac.jp

Received Date: Jun 04, 2022 / Published Date: Jul 05, 2022

Abstract

In Japan, the SARS-CoV-2 Omicron (B.1.1.529) variant has been spreading rapidly since the first case was detected in November 2021. Although this variant has been reported to have immune escape potential and SARS-CoV-2 mRNA vaccines have been reported to be less effective against this variant, the protective effect can be increased by a third dose of vaccine. In National Hospital Organization Hakodate National Hospital, an outbreak of the Omicron variant involving more than 30 Healthcare Workers (HCWs) and 90 hospital inpatients occurred in February 2022, despite most hospital staff having received three doses of vaccine. 95% confidence intervals for the ratio of the median antibody titers were 0.71 to 1.86 and there was no significant difference in antibody titers after the third vaccination between infected and non-infected HCWs. Although all cases of SARS-CoV-2 infection in HCWs were asymptomatic or mild, a third dose of mRNA vaccine may be insufficient to prevent infection with the Omicron variant or vaccine-induced antibody titers may not reflect the preventive effect against Omicron.

Keywords: SARS-CoV-2 Omicron variant; Outbreak; mRNA vaccine; Booster dose; Healthcare workers

Citation: Otsuka S, Hiraoka K, Suzuoki M, Ujiie H, Kato T, et al. (2022) Outbreak of SARS-CoV-2 Associated with Omicron Variant Infection in Healthcare Workers in Japan. J Infect Dis Ther 10: 503. Doi: 10.4172/2332-0877.1000503

Copyright: © 2022 Otsuka S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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