Abstract

Objectives: S. aureus bacteremia (SAB) is a leading cause of infection in patients with chronic kidney disease (CKD). Clinical outcomes associated with SAB in patients with CKD and with non-CKD were compared.

Materials and methods: Laboratory and clinical data from patients who were hospitalized with SAB in a tertiary care hospital were reviewed. Linear regression was used to identify independent predictors of 7-day, 30-day, and 90- day mortality.

Results and discussion: A total of 79 patients with CKD and 92 patients without CKD were enrolled from Mar 2014 to Dec 2016. Seven-day and 90-day mortality were increased in patients with CKD compared to patients with non-CKD (7-day mortality, 19% vs. 8.7%, p=0.011; 30-day mortality, 30.4% vs. 23.9%, p=0.058; 90-day mortality, 38.0% vs. 26.1%, p=0.002). Difference of Pitt bacteremia score and persistent bacteremia longer than 7 days among both groups was not statistically significant. High SOFA (sequential organ failure assessment) score and proportion of administration of inappropriate antibiotics was associated with CKD.

Conclusion: SAB bacteremia in CKD was combined with high SOFA score. Administration of inappropriate antibiotics might cause high mortality in patients with CKD.

Keywords: Staphylococcus aureus; Bacteremia; Chronic kidney disease