Abstract

Pain management in patients with genetic epilepsies and neurogenetic disorders presents unique challenges in palliative care, where the focus is on comfort and quality of life rather than cure. Conditions such as Dravet syndrome, Rett syndrome, and tuberous sclerosis complex (TSC) often involve refractory seizures, spasticity, and neuropathic pain, compounded by cognitive and communication impairments. This article explores palliative strategies tailored to these patients, integrating pharmacological, non-pharmacological, and interdisciplinary approaches. By synthesizing recent evidence, it demonstrates how such methods alleviate suffering and support families. The findings emphasize the need for individualized, holistic care to address the complex pain profiles in this population.