Abstract

Parkinson’s ailment is the second most frequent neurodegenerative ailment after Alzheimer’s disease. Most instances are sporadic, alternatively familial instances do exist. We examined 12 households with familial Parkinson’s sickness ascertained at the Movement Disorder medical institution at the Oregon Health Sciences University for genetic linkage to a wide variety of candidate loci. These loci have been implicated in familial Parkinson’s sickness or in syndromes with a medical presentation that overlaps with parkinsonism, as nicely as probably in the pathogenesis of the disease.