Abstract

Pharmacokinetics (PK) is the branch of pharmacology concerned with the study of the absorption, distribution, metabolism, and excretion (ADME) of drugs in the body. This field plays a crucial role in drug development, as it determines the optimal dosage, safety, efficacy, and overall therapeutic potential of pharmaceutical agents. This book explores the core principles of pharmacokinetics, from basic concepts to advanced modeling techniques, and discusses how these principles are applied in the development of new drugs. Emphasizing the integration of PK data into preclinical and clinical studies, it provides insights into dose optimization, therapeutic drug monitoring, and the impact of genetic variability on drug response. Real-world case studies and the latest advancements in the field, including population pharmacokinetics and physiologically based pharmacokinetic (PBPK) modeling, are also covered. This resource is designed for researchers, students, and professionals engaged in drug discovery and development, as well as those interested in understanding the complex interplay between drugs and the human
body.