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Pharmacokinetics of Antibodies: Understanding the Dynamics of Therapeutic Antibodies in the Body | OMICS International| Abstract

Journal of Pharmacokinetics & Experimental Therapeutics
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  • Review Article   
  • J Pharmacokinet Exp Ther 7: 182,
  • DOI: 10.4172/jpet.1000182

Pharmacokinetics of Antibodies: Understanding the Dynamics of Therapeutic Antibodies in the Body

Kim Zang*
Department of Pharmacy, The Affiliated Suzhou Hospital of Nanji Medical University, Suzhoang Municipal Hospital, Suzhoang, China
*Corresponding Author : Kim Zang, Department of Pharmacy, The Affiliated Suzhou Hospital of Nanji Medical University, Suzhoang Municipal Hospital, Suzhoang, China, Email: kim@zang.edu

Received Date: Jun 02, 2023 / Published Date: Jun 29, 2023

Abstract

Antibodies have become essential tools in the field of biomedicine, with an increasing number of therapeutic antibodies being developed for the treatment of various diseases. Understanding the pharmacokinetics of these antibodies is crucial for optimizing their therapeutic efficacy and minimizing potential adverse effects. This review aims to provide a comprehensive overview of the pharmacokinetics of antibodies, including their absorption,distribution, metabolism, and excretion (ADME) profiles. The absorption of antibodies following different routes of administration, such as intravenous, subcutaneous, and intramuscular, is discussed, highlighting factors that influence their bioavailability and onset of action. The distribution of antibodies within the body, including their tissue penetration and interaction with target antigens, is examined to elucidate their potential therapeutic targets and limitations. The metabolism and elimination pathways of antibodies, involving processes such as proteolysis and clearance, are explored, emphasizing the role of the immune system and the impact of disease states on antibody pharmacokinetics. Factors affecting antibody half-life and dosing regimens, such as antibody size, target antigen expression, and the presence of neutralizing antibodies, are also examined.

Citation: Zang K (2023) Pharmacokinetics of Antibodies: Understanding theDynamics of Therapeutic Antibodies in the Body. J Pharmacokinet Exp Ther 7:182. Doi: 10.4172/jpet.1000182

Copyright: © 2023 Zang K. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.

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