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Pharmacokinetics of Olanzapine: A Comprehensive Review | OMICS International| Abstract

Journal of Pharmacokinetics & Experimental Therapeutics
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  • Review Article   
  • J Pharmacokinet Exp Ther 7: 183,
  • DOI: 10.4172/jpet.1000183

Pharmacokinetics of Olanzapine: A Comprehensive Review

Dam Arkin*
Department of Marine and Environmental Research, Ruder Boskovic Institute, Canada
*Corresponding Author : Dam Arkin, Department of Marine and Environmental Research, Ruder Boskovic Institute, Canada, Email: dam.arkin@gmail.ca

Received Date: Jun 02, 2023 / Published Date: Jun 29, 2023

Abstract

Olanzapine is a widely prescribed antipsychotic medication used in the management of various psychiatric disorders, including schizophrenia and bipolar disorder. Understanding the pharmacokinetics of olanzapine is crucial for optimizing dosing strategies, predicting drug interactions, and ensuring therapeutic efficacy and safety.This review aims to provide a comprehensive overview of the pharmacokinetic profile of olanzapine, including its absorption, distribution, metabolism, and elimination. Olanzapine is primarily administered orally and is rapidly and extensively absorbed from the gastrointestinal tract. Its bioavailability is high, reaching approximately 60-65% due to first-pass metabolism. Food intake does not significantly affect its absorption. Once absorbed, olanzapine exhibits a large volume of distribution, indicating extensive tissue distribution. It binds extensively to plasma proteins, mainly albumin, which may influence its pharmacokinetic interactions with other highly protein-bound drugs. Olanzapine is metabolized primarily in the liver by the cytochrome P450 enzyme system, mainly CYP1A2, resulting in the formation of multiple metabolites. These metabolites, including N-desmethyl-olanzapine and 2-hydroxy-olanzapine, exhibit pharmacological activity but are generally less potent than the parent compound.

Citation: Arkin D (2023) Pharmacokinetics of Olanzapine: A ComprehensiveReview. J Pharmacokinet Exp Ther 7: 183. Doi: 10.4172/jpet.1000183

Copyright: © 2023 Arkin D. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.

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