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Plasma Cell Mastitis Resembling a Breast Cancer: A Case Report and Review of the Literature | OMICS International| Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Review Article   
  • J Infect Dis Ther 2017, Vol 5(6): 346
  • DOI: 10.4172/2332-0877.1000346

Plasma Cell Mastitis Resembling a Breast Cancer: A Case Report and Review of the Literature

Katic V1*, Stosic D2, Rankovic A3, Simonovic M4, Todorovic J5, Mladenovic M5, Jovic A5 and Stojanovic M5
1Policlinic Human, , Nis, Serbia
2Clinic for Gynecology and Obstetrics, Clinical Center Nis, , Nis, Serbia
3Clinic for Infectious Diseases, Clinical Center Nis, , Nis, Serbia
4Clinic for Mental Health Care, Clinical Center Nis, School of Medicine, University of NIS, Nis, Serbia
5Medical Faculty, University of NIS, Nis, Serbia
*Corresponding Author : Katic V, Policlinic Human, University of NIS, Nis, Serbia, Tel: +00381 18 533190, Email:

Received Date: Dec 18, 2017 / Accepted Date: Dec 21, 2017 / Published Date: Dec 26, 2017


Plasma Cell Mastitis (PCM) is a benign breast entity that occurs in females in middle age with main histopathological characteristic-infiltration of plasma cells and lymphocytes in breast tissue. The importance of PCM lies in his similarity to the breast cancer in a clinical, microscopical and macroscopical presentation. Different stages of the PCM can resemble different diseases, such as tuberculosis, periductal mastitis, inflammatory and ductal breast carcinoma. A 35-year-old woman was presented with a subareolar firm mass in the right breast, 5 cm in size, followed by nipple discharge and retraction, which clinically mimicked breast carcinoma. The patient was treated surgically. We detected centered or subareolar dilated ducts, with fibrous thickening of the wall and foamy macrophages. The sections are composed of fibro-fatty tissue, with areas of indurations that contained hyperemic capillaries and granulocytic-eosinophilic leucocytes. The exudate contained thick-tan-yellow colored secretion, cholesterol crystals, “lipophagic polyps” and calcification. Intraductal epithelium was atrophic, dysplastic with papillomatosis or squamous metaplasia. Late lesions of periductal fibrosis and “Gareland pattern” were reported. Unclear etiology of PCM, mimicking of the other granulomatous lesions and challenges in diagnosis and treatment, as described in the literature, were observed in our case. Our aim was to present rarity of the disease and challenges in the diagnosis and treatment.

Keywords: Plasma cell mastitis; Breast cancer; Diagnosis; Treatment; Mimicking

Citation: Katic V, Stosic D, Rankovic A, Simonovic M, Todorovic J, et al. (2017) Plasma Cell Mastitis Resembling a Breast Cancer: A Case Report and Review of the Literature. J Infect Dis Ther 5: 346. Doi: 10.4172/2332-0877.1000346

Copyright: ©2017 Katic V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.