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Prevalence and Outcomes of Familial Hypercholesterolemia Patients in a Chinese Myocardial Infarction Cohort | OMICS International| Abstract

Atherosclerosis: Open Access
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  • Research Article   
  • Atheroscler Open Access 2017, Vol 2(2): 114

Prevalence and Outcomes of Familial Hypercholesterolemia Patients in a Chinese Myocardial Infarction Cohort

Yan Gao1#, Hong Yin2#, Ying He2, Jihua Wu2, Siming Wang1, Wenjin Li2, Xi Li1, Ouhong Wang2, Mingqiang Zhang2 and Lixin Jiang1*
1National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, , 167 Beilishi Road, Beijing, 100037, PR China
2Amgen Biopharmaceutical Research & Development (Shanghai) Co., Ltd, , Shanghai, China 4F, Building 6, 99 Haike Road, Shanghai, 201210, PR China
#Contributed equally to this work
*Corresponding Author : Lixin Jiang, National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease FuWai Hospital, National Center for Cardiovascular Diseases, 167 Beilishi Rd. Beijing 100037, PR China, Tel: +86 10 8839 6203, Fax: +86 10 8836 5201, Email: [email protected]

Received Date: Aug 16, 2017 / Accepted Date: Aug 21, 2017 / Published Date: Aug 24, 2017

Abstract

Background and aims: Familial Hypercholesterolemia (FH) is an inherited metabolic disorder with increased LDL-C levels and coronary heart disease (CHD) risk. The prevalence of heterozygous FH is approximately 1:200 to 1:500 worldwide and higher in CHD populations. We aim to estimate the prevalence of FH and the incidence of recurrent cardiovascular events among FH and non-FH patients in a large myocardial infarction cohort in China.

Methods: We studied the cohort from the China Patient-Centered Evaluative Assessment of Cardiac Events Prospective study (PEACE-Prospective). The eligible cohort included 3367 patients hospitalized for myocardial infarction (MI).

Results: The proportion of potential FH was 0.80% and 4.28% by Dutch Lipid Clinic Network (DLCN) and modified DLCN criteria, respectively. Compared to non-FH, the FH patients were younger, having more personal and family history of premature CHD, current smokers and overweight. The exome sequencing identified 11 cases of pathogenic variants on LDL receptor and ApoB. The risk of recurrent cardiovascular events after MI was greater in FH patients with a hazard ratio (HR) of 1.97 with modified DLCN.

Conclusions: The prevalence of Chinese FH by modified DLCN is comparable to the European estimate by DLCN in the high cardiovascular risk cohort. The patients with FH compared to non-FH have an almost 2-fold adjusted risk of recurrent cardiovascular events. Further consensus on the LDL-C-based threshold may help on the establishment of country specific criteria for FH.

Keywords: Familial hypercholesterolemia; Dutch lipid clinic network criteria; Modified dutch lipid clinic network criteria

Citation: Gao Y, Yin H, He Y, Wu J, Wang S, et al. (2017) Prevalence and Outcomes of Familial Hypercholesterolemia Patients in a Chinese Myocardial Infarction Cohort. Atheroscler Open Access 2: 114.

Copyright: © 2017 Gao Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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