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Profile of Mucormycosis Cases from a Network of Hospitals in North India amidst COVID-19 Pandemic | OMICS International | Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Profile of Mucormycosis Cases from a Network of Hospitals in North India amidst COVID-19 Pandemic

Sandeep Budhiraja1*, Mona Aggarwal1, Monica Mahajan1, Abhaya Indrayan2, Vinita Jha2, Ambrish Mithal1, Sanjay Sachdeva1, Ritu Raj Barua1, Sumit Mrig3, Anurag Jain4, Ravinder Gera5, Rahul Aggarwal6, Suven Kalra7, WVPS Ramalingam8, Anupal Deka9, Arjun Das10, D Jijina1, Ajit Mansingh1, Anuj Singhal1, Rajashekhar Reddi1, Puneet Aggarwal1, Mukesh Kumar1, JD Mukherjee1, Vivek Nangia1, Ajay Lall1, Omender Singh1, Arun Dewan3, Ajay Jain4, Gita G Shrivastava4, Mala Bhattacharjee4, Meena Nihalani4, Manoj Kumar44, Meenakshi Jain4, Mukesh Mehra4, Vijay Arora4, Viresh Prashant Mehta4, Dilip Bhalla44, Amit Batra4, Rajesh Gupta4, Vivek Kumar4, Sanjeev Dua4, Praveen Pandey4, Y P Singh4, Mohit Mathur5, Ashok Singh6, Sanjeev Arora6, Ajay Kumar Gupta6, Pankajnand Choudhary6, Manoj Singh6, Namita Kaul6, Sitla Prasad Pathak6, Sharad Joshi6, Manish Gupta6, Rajesh Mishra7, Alok Joshi7, Manoj Aggarwal7, Rajiv Gupta7, Vandana Boobna7, Yogesh Kumar Chhabra7, Inder Mohan Chugh7, Sandeep Garg7, Vikas Mittal7, Neha Sood8, Anil Kumar8, Rajesh Kumar Pande8, V P Singh8, Iram Khan9, Nitin Garg9, Puneet Tyagi9, Shantanu Belwal9, Anup Kumar Roy10, Deepak Bhasin10, Sachin Pandove10, Ravikant Bahl10 and Prateek Soni10
1Max Super Speciality Hospital, Saket, New Delhi, India
2Department of Clinical Directorate, Max Healthcare, New-Delhi, India
3Max Smart Super Speciality Hospital, Saket, New Delhi, India
4Max Super Speciality Hospital, Patparganj, New Delhi, India
5Max Hospital, Gurgaon, Haryana, India
6Max Super Speciality Hospital, Vaishali, Uttar Pradesh, India
7Max Super Speciality Hospital, Shalimar Bagh, New Delhi, India
8BLK-Max Super Speciality Hospital, New Delhi, India
9Max Super Speciality Hospital, Dehradun, Uttarakhand, India
10Max Super Speciality Hospital, Mohali, Punjab, India
*Corresponding Author: Sandeep Budhiraja, Max Healthcare, Institute of Internal Medicine, Max Super Speciality Hospital, Saket, New-Delhi, India, Tel: + 91 9810262954;, Email: [email protected]

Received Date: Oct 04, 2021 / Accepted Date: Oct 18, 2021 / Published Date: Oct 25, 2021

Citation: Budhiraja S, Aggarwal M, Mahajan M, Indrayan A, Jha V, et al. (2021) COVID-19 Outcomes in Pregnancy: A Review of 275 Screened Studies Profile of Mucormycosis Cases from a Network of Hospitals in North India amidst COVID-19 Pandemic. J Infect Dis Ther S5:004.

Copyright: © 2021 Budhiraja S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Incidence of mucormycosis suddenly surged in India after the second wave of COVID-19. This is a crippling disease and needs to be studied in detail to understand the disease, its course, and the outcomes. Between 1st March and 15th July 2021, our network of hospitals in North India received a total of 155 cases of COVID-associated mucormycosis cases as all of them reported affliction by COVID-19 earlier or concurrent. Their records were retrieved from the Electronic Health Records system of the hospitals and their demographics, clinical features, treatments, and outcomes were studied. More than 80% (125 cases) had proven disease and the remaining 30 were categorized as ‘possible’ mucormycosis as per the EORTC criteria. More than two-thirds (69.0%) of the cases were males and the mean age was 53 years for either sex. Nearly two-thirds (64.5%) had symptoms of nose and jaws and 42.6% had eye involvement. Some had multiple symptoms, as many as 78.7% had diabetes and 91.6% gave history of use of steroids during COVID-19 treatment. The primary surgery was functional endoscopic sinus surgery (FESS) (83.9%). Overall mortality was 16.8%, which is one-and-a-half times the mortality in hospitalized COVID-19 patients in the corresponding population. Occurrence of mucormycosis was associated with diabetes and use of steroids, but mortality was not associated with either of them. Cases undergoing surgery and on antifungal had steeply lower mortality (11.9% vs. 50.0%, P<0.001) than those who were exclusively on antifungal drugs. Treatment by different drugs did not make much of a difference in mortality.

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