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Protective Effect of Ginger (Zingiber officinale) on Alzheimer's disease Induced in Rats | OMICS International| Abstract
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
Open Access

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  • Research Article   
  • JNID 2014, Vol 5(2): 159

Protective Effect of Ginger (Zingiber officinale) on Alzheimer's disease Induced in Rats

Karam A Mahdy1*, Nadia AM Gouda2, Abd El-Fattah H Marrie2, Nemat AZ Yassin3, Siham MA El-Shenawy3, Abdel Razik H Farrag4 and Bassant MM Ibrahim3
1Department of Medical Biochemistry, National Research Center, Cairo, Egypt
2Department of Pharmacology, Faculty of Medicine, Cairo University, Cairo, Egypt
3Department of Pharmacology, National Research Center, Cairo, Egypt
4Department of Pathology, National Research Center, Cairo, Egypt
*Corresponding Author : Karam A Mahdy, Department of Medical Biochemistry, National Research Center, Cairo, Egypt, Tel: +202-37494783, Email: [email protected]

Received Date: Mar 11, 2014 / Accepted Date: Jun 04, 2014 / Published Date: Jun 12, 2014

Abstract

The possible protective effect of Ginger on Alzheimer’s disease induced in rats was investigated. Ninety rats were used as follows: control group, AD protective group using AlCl3, 3rd, 4th, and 5th groups rats were received orally Rivastigmine, Ginger (108 and 216 mg/kg/day) respectively, for two weeks followed by combination of each treatment for another 4 weeks. 6th group is a therapeutic AD group, while 7th, 8th & 9th groups are AD rats treated with the same doses of Rivastigmine and Ginger for 12 weeks. At baseline and after each treatment, behavioral stress tests, Rotarod and T-Maze tests were done. At the end of all experiments rats' brains were dissected and prepared for determination of acetylcholine (Ach), acetycholinesterase (AchE) levels and histopathologic examination. This study indicated that AD-induced rats exhibited reduction in behavior, Rotarod and T-Maze tests, reduction in brain Ach and increase AchE levels. While rats treated with Rivastigmine and Ginger in protective and therapeutic groups exhibited significant improvement in behavior, Rotarod and T-Maze, significant increase in brain Ach and decrease AchE levels. These results were consistent with the histopathological findings and revealed Rivastagmine, and Ginger ameliorates neurodegeneration characters of Alzheimer’s diseases in rats.

Keywords: Alzheimer’s disease; Aluminum chloride; Ginger; Therapeutic; Protective; Rats

Citation: Karam AM, Nadia AMG, Abd El-FHM, Nemat AZY, Siham MAES, et al. (2014) Protective Effect of Ginger (Zingiber officinale) on Alzheimer's disease Induced in Rats. J Neuroinfect Dis 5:159.

Copyright: © 2014 Karam AM et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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