Recurrent Head Trauma: A Trigger of the Alzheimer Cascade or the Cause of an Independent Pathologic Entity? - An Explicative Case of Chronic Traumatic Encephalopathy Mimicking Alzheimer's Disease
Received Date: Nov 30, 2017 / Accepted Date: Dec 13, 2017 / Published Date: Dec 20, 2017
Repeated traumatic brain injuries have a negative impact on brain integrity and cognition. It was hypothesized that they could trigger the AD amyloidogenic cascade or they could represent a peculiar clinical entity labelled as “chronic traumatic encephalopathy”, CTE. To contribute in the understanding of this controversy we describe the case of a boxer with early onset dementia, reporting biomarkers and neuropsychological assessment with the effort to differentiate the AD diagnosis and CTE. We discuss, for each element, it’s possible role with regard to the opposite diagnostic directions and we highlight, on the example of our probable CTE patient, the necessity of better defined diagnostic criteria for the chronic traumatic encephalopathy.
Keywords: Traumatic brain injuries; Chronic traumatic encephalopathy; Alzheimer’s disease; Dementia
Citation: Grande G, Galimberti D, Maggiore L, Scarpini E, Mariani C, et al. (2017) Recurrent Head Trauma: A Trigger of the Alzheimer Cascade or the Cause of an Independent Pathologic Entity? - An Explicative Case of Chronic Traumatic Encephalopathy Mimicking Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 7: 408. Doi: 10.4172/2161-0460.1000408
Copyright: © 2017 Grande G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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