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Regulative Effect for Granulocyte/Lymphocyte Ratio by Malted Rice through Complement Activation in Human Peripheral Blood | OMICS International| Abstract
ISSN: 2573-4555

Journal of Traditional Medicine & Clinical Naturopathy
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  • Research Article   
  • J Tradit Med Clin Natur 2018, Vol 7(1): 262
  • DOI: 10.4172/2573-4555.1000262

Regulative Effect for Granulocyte/Lymphocyte Ratio by Malted Rice through Complement Activation in Human Peripheral Blood

Hisashi Tsukada1, Kazuhiro Okamoto2, Nurmuhamamt Amat3 and Nobuo Yamaguchi1,4*
1Ishikawa Natural Medicinal Products Research Center, , Ishikawa, Japan
2Department of Rehabilitation, Kanazawa Medical University, Ishikawa, Japan
3Department of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi, China
4Department of Fundament Research for CAM, Kanazawa Medical University, Ishikawa, Japan
*Corresponding Author : Nobuo Yamaguchi, Ishikawa Medicinal Products Research Center, Kanazawa, Japan, Tel: +81-76-286-2211 Exn. 3921, Fax: +81-76-286-2841, Email: [email protected]

Received Date: Jan 09, 2018 / Accepted Date: Feb 01, 2018 / Published Date: Feb 08, 2018

Abstract

Background: A Life-related diseases had been claimed to regulated by finding some alternative medicinal process.
Objective: The purpose of this study was to find cool method to control the bias from life-related disease through granulocyte-lymphocyte ratio in human.
Method: A malted rice were prepared by Rice Yeast (MRY). This products were exhibited by safe in animal safety test. The trial was made to investigate a recovery of immune-competent cells both in granulocyte and lymphocyte ratio and CD positive lymphocyte subpopulations together with the amount of emotional hormone adrenalin and dopamine.
Result: Our results in animal model showed that MRY was the safe for the animal safety test. Four weeks after the administration, granulocyte and lymphocyte ratio was regulated as modulate and neutral. The emotional hormone adrenaline and dopamine level in serum also regulated neutral that dose dependent and reversible manner. The mechanism of this regulation had triggered by starting complement activation by absorbed MRY fragments through intestinal wall to the lymph.
Conclusion: We proposed an idea that MRY exhibited remedy effect for the regulation of immune competent cells via controlling complement component. The mechanism of activation was proved by activating alternative pathway of complement by the technic, immune-electrophoresis.

Keywords: Yeast; Fermentation; Molted rice; Granulocyte; Lymphocyte; Leucocyte subset ratio; Adrenalin; Dopamine; Alternative complement activation

Citation: Tsukada H, Okamoto K, Amat N, Yamaguchi N (2018) Regulative Effect for Granulocyte/Lymphocyte Ratio by Malted Rice through Complement Activation in Human Peripheral Blood. J Tradit Med Clin Natur 7: 262. Doi: 10.4172/2573-4555.1000262

Copyright: © 2018 Tsukada H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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