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Residual Hepatic HCV-RNA in the Native Liver of Living Donor Liver Transplant Recipients with Chronic Hepatitis C: Mini-Review | OMICS International| Abstract

Journal of Oncology Research and Treatment
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  • Mini Review   
  • J Oncol Res Treat,

Residual Hepatic HCV-RNA in the Native Liver of Living Donor Liver Transplant Recipients with Chronic Hepatitis C: Mini-Review

Shu Hsien Lin1,2, Chih Chi Wang2,3*, Kuang Tzu Huang2,4, Kuang Den Chen2,4, Chih Che Lin2,3, Li Wen Hsu2 and King Wah Chiu1,2,3*
1Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
3Department of Surgery, College of Medicine, Chang Gung University, Taoyuan, Taiwan
4Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
*Corresponding Author (s) : Prof. Chih Chi Wang, Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Tel: +886-7-731-7123 Exn. 8301, Fax: +886-7-733-6856, Email: [email protected]
Prof. King Wah Chiu, Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Tel: +886-7-731-7123 Exn. 8301, Fax: +886-7-733-6856, Email: [email protected]

Received Date: Sep 08, 2021 / Accepted Date: Sep 22, 2021 / Published Date: Sep 29, 2021

Abstract

Chronic Hepatitis C Virus (HCV) infection is the leading risk factor for Hepatocellular Carcinoma (HCC), with an annual HCC risk of 2%-4% in cirrhotic patients. With the highly effective and safe direct-acting antiviral (DAA) therapy, HCV infection would be considered “cured and eliminated” successfully in >95% treated patients. However, even with the widespread use of direct-acting antivirals, Living Donor Liver Transplantation (LDLT) plays an important role in advanced liver disease. According to our recent observation, the pre-transplant serum HCV RNA levels may give an underestimate of the number of positive HCV RNA cases and that hepatic HCV RNA data may be more accurate.

Herein, we would like to have a mini review to detailed address issues including the significance of hepatic HCV RNA and the discrepancy between hepatic HCV RNA and HCV core antigen in native liver of chronic hepatitis C recipients undergoing LDLT, a new insight into cure and complete elimination of HCV infection and the utilization of HCV-aviremic organs into aviremic recipients in liver transplantation.

Keywords: Hepatitis C virus; Hepatocellular carcinoma; HCV RNA; Direct-acting antiviral agents; Liver transplantation

Citation: Lin SH, Wang CC, Huang KT, Chen KD, Lin CC (2021) Residual Hepatic HCV-RNA in the Native Liver of Living Donor Liver Transplant Recipients with Chronic Hepatitis C: Mini-Review. J Oncol Res Treat 6:167.

Copyright: © 2021 Lin SH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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