alexa Role of In-silico modeling in Drug Development for Inhalation Treatment | OMICS International| Abstract
ISSN: 2329-9053

Journal of Molecular Pharmaceutics & Organic Process Research
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  • Short Communication   
  • J Mol Pharm Org Process Res 2013, Vol 1(2): 106
  • DOI: 10.4172/2329-9053.1000106

Role of In-silico modeling in Drug Development for Inhalation Treatment

Shengqian Wu1, Sharareh Salar-Behzadi2 and Eleonore Fröhlich E1,2*
1Research Center, Pharmaceutical Engineering GmbH, , Inffeldgasse 21a, 8010 Graz, Austria
2Center for Medical Research, Medical University of Graz, Stiftingtalstr. 24, 8010 Graz, Austria
*Corresponding Author : Eleonore Fröhlich E, Center for Medical Research, Medical University of Graz, Austria, Email: [email protected]

Received Date: Aug 28, 2013 / Accepted Date: Sep 23, 2013 / Published Date: Oct 04, 2013


In-silico modeling is increasingly being used for simulation of adsorption, distribution, metabolization, and excretion to predict the curve of plasma levels and bioavailabilityof oral drug formulations. Computational models for the prediction of other application routes are less common. Preliminary data shows that GastroPlusTM simulation software appears suitable for prediction of drug plasma levels of inhaled drugs in healthy individuals. Since also the influence of physiological variations on lung deposition can be simulated, this software could be a valuable tool in the screening of promising formulations.

Keywords: In-silico modeling; Gastroplus™; Budesonide; Turbohaler

Citation: Shengqian Wu, Salar-Behzadi S, Fröhlich E (2013) Role of In-silico modeling in Drug Development for Inhalation Treatment. J Mol Pharm Org Process Res 1: 106. Doi: 10.4172/2329-9053.1000106

Copyright: ©2013 Shengqian Wu, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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