SARS-Cov-2 Breakthrough Infections in Fully Vaccinated Individuals in a University Setting | OMICS International| Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Research Article   
  • J Infect Dis Ther,
  • DOI: 10.4172/2332-0877.1000468

SARS-Cov-2 Breakthrough Infections in Fully Vaccinated Individuals in a University Setting

Esteban Ramirez*, Rebecca P, Giovanna Carpi, Jack Dorman, Craig Bowen and Lisa Smith
1Department of Medicine, Indiana University, West Lafayette, USA
2Department of Comparative Pathobiology/Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, USA
3Department of Biological Sciences, Purdue University/Purdue Institute of Inflammation, West Lafayette, USA
4Department of Biological Sciences, Purdue University, West Lafayette, USA
5Department of Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, USA
6Department of Surgery, University of Tennessee College of Medicine, Chattanooga, USA
*Corresponding Author : Esteban Ramirez, Department of Medicine, Indiana University, West Lafayette, USA, [email protected]

Received Date: Jul 02, 2021 / Accepted Date: Jul 16, 2021 / Published Date: Jul 23, 2021


Study background: The SARS CoV2 pandemic has led to many severe infections and deaths. With the development of vaccines, we are now seeing declining numbers of infections. However, individuals that get fully vaccinated may still experience a breakthrough infection. Are these infections clinically significant?

Methods: This study was performed as part of a surveillance program for SARS-CoV-2 on a university campus with 49,700 students and employees. Surveillance testing was random and included approximately 10% of the population each week. Additionally, individuals self-identified with COVID-19 related symptoms or those that had close contact with SARS-CoV-2 positive individuals were also tested. Anterior nasal swabs were collected from individuals for a Nucleic Acid Amplification Test (NAAT) for detection of SARS-CoV-2. A subset of NAAT positive samples was sequenced to determine variants associated with infections. Included in the testing and sequencing protocol were individuals that were fully vaccinated. We paired random and passive surveillance nucleic acid testing with analysis of viral whole genomic sequences to detect and describe breakthrough infections, focusing on a university community.

Conclusion: In this retrospective analysis, we identified breakthrough infections in 14 individuals out of 2,551 nucleic acid amplification tests performed from samples of fully vaccinated individuals from February to early May 2021. Cases were associated with all three of the currently EUA approved vaccines and were associated with 5 variants, including variants of concern/variants of interest. Our data support the need to continue surveillance and mitigation strategies, including active surveillance testing and viral genomic sequencing for variant characterization of asymptomatic infections, particularly but not limited to university settings.

Keywords: SARS CoV-2; Genetic sequencing; Variants of concern; Vaccines

Citation: Ramirez E, Rebecca P, Carpi G, Dorman J, Bowen C, et al. (2021) SARS-Cov-2 Breakthrough Infections in Fully Vaccinated Individuals in a University Setting. J Infect Dis Ther 9:468. Doi: 10.4172/2332-0877.1000468

Copyright: © 2021 Ramirez E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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