Abstract

Neuromyelitis optica (NMO) is a disabling, rare, inflammatory, autoimmune, demyelinating disease of the disorder of the central nervous system (CNS) that affects mainly his spinal cord and optic nerves results in severe attacks of optic neuritis and myelitis. The serum autoantibody against aquaporin-4 water channels, NMO-Immunoglobulin (NMO-IgG), is involoved in the disease and is found in up to 75% of patients with an NMO-spectrum disorder but if negative doesn’t exclude the disease. However, the cerebrospinal fluid (CSF) profile in NMO relapses is not well known and there is great variability in CSF profile in those patients, so here we describe one case of seronegative neuromyelitis optica spectrum disorder with CSF findings similar to bacterial meningitis.

Keywords: Neuromyelitis optica spectrum disorder; Aquaporin 4 antibodies; Optic neuritis; Myelitis; Bacterial meningitis