alexa Serum Hepcidin Level and Human Factors Engineering <em>(HFE) C282Y</em> Mutation in Egyptian Children with Beta-Thalassemia | OMICS International| Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • Biochem Physiol 2017, Vol 6(3): 223
  • DOI: 10.4172/2168-9652.1000223

Serum Hepcidin Level and Human Factors Engineering (HFE) C282Y Mutation in Egyptian Children with Beta-Thalassemia

Eman AE Badr1*, Mohamed Farag Ali Assar2, Mahmoud Ahmed El-Hawy3, Sara Rabea Ibrahim Saad El-dean2 and Ibrahim El Tantawy El Sayed4
1Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Egypt
2Department of Chemistry, Biochemistry Division, Faculty of Science, El-Menoufia University, , Shebin El koom, Egypt
3Department of Pediatrics, Faculty of Medicine, Menoufia University, Egypt
4Department of Organic and Medicinal Chemistry, Faculty of Science, Menoufia University, Egypt
*Corresponding Author : Eman AE Badr, Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Shebin Elkom City, Egypt, Tel: +201090365171, Fax: +20482181009, Email: [email protected]

Received Date: Jul 27, 2017 / Accepted Date: Aug 26, 2017 / Published Date: Sep 04, 2017

Abstract

Objective: Thalassemia is an important hematological disorder. The possibility of iron overload development may be increase by Interaction between thalassemia and HFE gene mutations. This study aim to investigate the possible association between serum hepcidin level as indicator of iron concentration and the presence of HFE gene mutations.
Methods: The study contains two groups, group I: include seventy six children with beta thalassemia, group II include 51 apparently healthy gender and age matched children served as controls. Children was passed through full history taking, clinical examination. Complete blood picture, iron, ferritin, hepcidin, renal and liver functions were measured. HFE gene C282Y mutation was assayed by SNP real time PCR.
Results: Frequency of the A genotype and A allele of HFE gene C282Y mutation shows a significant increase in beta thalassemia group in comparison controls. Also, serum Iron and ferritin levels were significantly increase with decrease in hepcidin level in AA when compared to AG and GG genotypes. The splenectomy percent was significantly increased among AA genotype in the patient group. The number and % of patients with ferritin level equal or more than 2500 ng/ml and decrease in hepcidin level as an index of iron overload was significantly increase in patients with AA and AG genotypes.
Conclusion: There were significant negative associations between serum hepcidin levels as indication of iron toxicity and HFE C282Y mutation in Egyptian Beta thalassemia children.

Keywords: TM; Hepcidin; HFE; Mutation

Citation: Badr EAE, Assar MFA, El-Hawy MA, El-dean SRIS, El Sayed IET (2017) Serum Hepcidin Level and Human Factors Engineering (HFE) C282Y Mutation in Egyptian Children with Beta-Thalassemia. Biochem Physiol 6: 223. Doi: 10.4172/2168-9652.1000223

Copyright: © 2017 Badr EAE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Article Usage
  • Total views: 2209
  • [From(publication date): 0-2017 - Dec 01, 2020]
  • Breakdown by view type
  • HTML page views: 2089
  • PDF downloads: 120
Top