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Significant Method in Drug Disposition and is that the Most Relevant Method in Stereoselectivity | OMICS International| Abstract

Journal of Pharmacokinetics & Experimental Therapeutics
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  • Mini Review   
  • J Pharmacokinet Exp Ther 2022, Vol 6(4): 149

Significant Method in Drug Disposition and is that the Most Relevant Method in Stereoselectivity

Annan Valdese*
Department of Clinical Pharmacology, University Medical Centre Gottingen, Germany
*Corresponding Author : Annan Valdese, Department of Clinical Pharmacology, University Medical Centre Gottingen, Germany, Email:

Received Date: Aug 03, 2022 / Published Date: Aug 29, 2022


Stereoselectivity in drug metabolism can't solely influence the pharmacologic activities; tolerability, safety, and bioavailability of medicine directly, however additionally cause completely different forms of drug–drug interactions.Thus, assessing stereo selectivity in drug metabolism is of nice significance for pharmaceutical analysis and development (R&D) and rational use in clinic. Though there square measure numerous strategies accessible for assessing stereo selectivity in drug metabolism, several of them have shortcomings. The indirect technique of natural action strategies will solely be applicable to specific samples with purposeful teams to be derivative or type complicated with a chiral selector, whereas the direct technique achieved by chiral stationary phases (CSPs) is dear. As a detector of natural action strategies, mass spectroscopy (MS) is very sensitive and specific, whereas the matrix interference continues to be a challenge to beat. Additionally, the utilization of nuclear resonance (NMR) and bioassay in chiral analysis square measure price noting. This review presents many typical samples of drug stereo selective metabolism and provides a literature-based analysis on current chiral analytical techniques to indicate the importance and challenges of stereo selectivity assessing strategies in drug metabolism [1].

Citation: Valdese A (2022) Significant Method in Drug Disposition and is that the Most Relevant Method in Stereoselectivity. J Pharmacokinet Exp Ther 6: 149.

Copyright: © 2022 Valdese A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.