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Sodium Oxybatefor Narcolepsy with Cataplexyandndash; Cost-Effective Analysis | OMICS International| Abstract
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
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  • Research Article   
  • JNID 2014, Vol 5(2): 161

Sodium Oxybatefor Narcolepsy with Cataplexy– Cost-Effective Analysis

Lanting Lu1,2*, Chris Roome3, Lain Lang2,3 and Ken Stein1,2
1Peninsula Technology Assessment Group (PenTAG), Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
2Peninsula Collaboration for Leadership in Applied Health Research and Care (PenCLAHRC), Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
3Public Health Directorate, NHS Devon, UK
*Corresponding Author : Lanting Lu, Veysey building, Salmon Pool Lane, Exeter, EX2 4SG, UK, Tel: +44(0)1392 726069, Email: [email protected]

Received Date: Apr 18, 2014 / Accepted Date: Jun 25, 2014 / Published Date: Jul 02, 2014


Objective: To assess the cost-effectiveness of sodium oxybate plus antidepressants and stimulants compared with the current standard treatment for narcolepsy with cataplexy in the UK. Methods: We developed a Markov model to assess the costs and benefits of sodium oxybate plus antidepressants and stimulants or current standard treatment based on their effects on the quality of life of patients. The main outcome was the incremental cost-effectiveness ratio (ICER) in terms of costs per additional qualityadjusted life year (QALY) gained over 5 years of treatment. One-way, multi-way and probabilistic sensitivity analyses were conducted to explore the impact of uncertainties on the findings. Results: The cost-effectiveness of sodium oxybate plus antidepressants and stimulants were very sensitive to the costs of sodium oxybate (price and dose) and differences in utilities between responders and non-responders. With current clinical evidence, it is recognised that measure of improvement in utilities used in the current model may be an underestimation of the reality. Conclusions: Our analysis suggests that, at the current UK list price, sodium oxybate would not represent good value for money for the NHS. This is unfortunate, since it appears that sodium oxybate is likely to benefit some patients in the management of these two conditions which affect about 0.03% of the UK population.

Keywords: Cost-utility analysis; Sodium oxybate; Narcolepsy; Cataplexy; Quality of life; Economic evaluation; Probability sensitivity analysis

Citation: Lanting L, Chris R, Lain L, Ken S (2014) Sodium Oxybate for Narcolepsy with Cataplexy–A Cost-Effective Analysis. J Neuroinfect Dis 5:161.

Copyright: © 2014 Lanting L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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