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Journal of Molecular Immunology
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  • Research Article   
  • J Mol Immunol 2017, Vol 1(1): 104

Some Hematological and Biochemical Changes Associated with Blood Transfusion in Sickle Cell Anaemia Patients

Augustina II1, Alfred EF2,3,4* and Marcellinus NU1
1Department of Hematology and Blood Transfusion Science, Delta State University Teaching Hospital, Oghara, Delta State, , Nigeria
2Department of Hematology and Immunology, College of Health Sciences, Igbinedion University, Okada, Nigeria
3Lahor Research and Medical Centre, 121 Old Benin-Agbor Road, Benin City, , Nigeria
4Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria
*Corresponding Author : Alfred EF, Department of Hematology and Immunology, College of Health Sciences, Igbinedion University, Okada, Nigeria, Tel: +234(0)8063327432, Email: [email protected]

Received Date: Nov 24, 2016 / Accepted Date: Dec 06, 2016 / Published Date: Dec 09, 2016

Abstract

Objective(s): The present study was designed to provide additional information on some hematological and biochemical changes associated with blood transfusion in sickle cell anemia (SCA) patients.
Materials and methods: A total of 86 subjects (aged between 20 and 40 years) were randomly studied. Among these were 30 multi-transfused SCA (≥ 3 units of blood per year), 30 rarely transfused SCA (<3 units of blood per year) and 26 apparently healthy individuals. The blood samples collected in EDTA were used for packed cell volume, haemoglobin concentration, total white blood cell count, and platelet count using Sysmex®, Automated Hematology analyser where the blood samples collected in the anticoagulant free vacutainers were used for total bilirubin, aspartate amino transferase, alanine amino transferase using Beckman’s autoanalyser. Statistical analysis was done using the student’s t-test. P<0.05 was considered significant.
Results: The PCV and HB concentration were significantly lower in both multi and rarely blood transfused subjects when compared with controls (P=0.001) whereas the WBC, PLT, total bilirubin, AST and ALT were significantly higher in both multi and rarely blood transfused subjects when compared with controls (P=0.001).
Conclusion: This study revealed a mild elevation of the liver function tests of the sickle cell anemia patients which are indicative of an increased red cell splenic sequestration and haemolysis regardless of blood transfusion.

Keywords: Blood transfusion; Immune response; Haemolysis; Sickle cell anaemia

Citation: Augustina II, Alfred EF, Marcellinus NU (2016) Some Hematological and Biochemical Changes Associated with Blood Transfusion in Sickle Cell Anaemia Patients. J Mol Immunol 2:104.

Copyright: © 2016 Augustina II, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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