alexa Stimulation of Anterior Thalamic Nucleus Protects Hippocampus Neural Injury in Kainic Acid-Induced Epileptic Rats | OMICS International| Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Research Article   
  • J Alzheimers Dis Parkinsonism 2017, Vol 7(5): 377
  • DOI: 10.4172/2161-0460.1000377

Stimulation of Anterior Thalamic Nucleus Protects Hippocampus Neural Injury in Kainic Acid-Induced Epileptic Rats

Na Yan1#, Ning Chen2#, Wei Gao1* and Wei Wang3,4*
1Department of Neurology, Peking University Shougang Hospital, Peking University, Beijing 100144, China
2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, 100069, China
4Systems and Intervention Research Center for Health, School of Medical Sciences, Edith Cowan University, Perth WA6027, Australia
#Contributed equally to this work
*Corresponding Author (s) : Wei Gao, School of Medical Sciences, Edith Cowan University, Perth WA6027, Australia, Tel: +61-8-6304 2626, Email: [email protected]
Wei Wang, Department of Neurology, Peking University Shougang Hospital, Peking University, Beijing 100144, China, Tel: +61-8-6304 2626, Email: [email protected]

Received Date: Sep 10, 2017 / Accepted Date: Sep 18, 2017 / Published Date: Sep 25, 2017

Abstract

Anterior nucleus of thalamus (ANT) stimulation has been proved to be effective in the treatment of refractory epilepsy, but the underlying mechanisms remain to be elucidated. We examined the role of ANT stimulation on hippocampal neuron death after seizures induced by kainic acid (KA). Our data showed that ANT stimulation could significantly rescue neurons from death induced by seizures, by reducing the release of cytochrome c (cyto c) and also via apoptosis-inducing factor (AIF) induced by seizures through inhibiting the activated caspase-9 and caspase-3. Our data suggest that ANT stimulation may protect against neuronal loss and reduce neuronal injury in the ipsilateral CA3 region of the hippocampus in the KA-induced epileptic rats, and the underlying mechanism may be mediated by inhibiting mitochondrial caspase-dependent (cyto c release and the subsequent cleavage of caspase-) and caspase-independent (nuclear translocation of AIF) apoptosis pathways.

Keywords: Epilepsy; Anterior nucleus of thalamus; Stimulation; Apoptosis; Neuroprotection; Cytochrome c; Apoptosis-inducing factor

Citation: Yan N, Chen N, Gao W, Wang W (2017) Stimulation of Anterior Thalamic Nucleus Protects Hippocampus Neural Injury in Kainic Acid-Induced Epileptic Rats. J Alzheimers Dis Parkinsonism 7: 377. Doi: 10.4172/2161-0460.1000377

Copyright:  © 2017 Yan N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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