alexa Taxane-Induced Neuropathic Pain: Current Evidence and Treating Strategies | OMICS International| Abstract
ISSN: 2167-0846

Journal of Pain & Relief
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Review Article   
  • J Pain Relief 2017, Vol 7(2): 311
  • DOI: 10.4172/2167-0846.1000311

Taxane-Induced Neuropathic Pain: Current Evidence and Treating Strategies

Vincenzo Pota1, Maria Beatrice Passavanti1, Pasquale Sansone1, Manlio Barbarisi2, Maria Caterina Pace1 and Caterina Aurilio1*
1Department of Women, Child, General and Specialistic Surgery, University of Campania “L. Vanvitelli”, , Napoli, Italy
2Institute of Neurosurgery, University of Cattolica, Rome, Italy
*Corresponding Author : Caterina Aurilio, Department of Women, Child, General and Specialistic Surgery, University of Campania “L. Vanvitelli”, Napoli, Italy, Tel: 00393664485084, Email: [email protected]

Received Date: Feb 26, 2018 / Accepted Date: Mar 06, 2018 / Published Date: Mar 22, 2018

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling adverse event of most of commonly used antineoplastic agents. Previous studies have focused on several chemotherapeutic agents and reported that CIPN incidence varies from 19% to >85%. The mechanisms underlying CIPN are currently unknown. However, different theories have been proposed including microtubules dysfunction, mitochondrial dysfunction and mitochondrial toxicity, Glial pathway, substance P pathway, adenosine receptor pathway. CIPN is not simply to treat, and most randomized controlled trials failed to identify an effective therapy. Recent evidence supports the efficacy of serotonin (5-HT) and norepinephrine (NE) dual reuptake inhibitors (SNRI) in the treatment of neuropathy-related pain. Based on current evidence, we can speculate that duloxetine and topical menthol would improve CIPN pain as symptomatic treatment while, based on preclinical data, pifithrin-μ could be considered in future for the prevention of CIPN.

Keywords: Neuropathic cancer pain; Chemotherapy induced peripheral neuropathy; Microtubules

Citation: Pota V, Passavanti MB, Sansone P, Barbarisi M, Pace MC, et al. (2018) Taxane-Induced Neuropathic Pain: Current Evidence and Treating Strategies. J Pain Relief 7: 311. Doi: 10.4172/2167-0846.1000311

Copyright: © 2018 Pota V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Relevant Topics
Article Usage
  • Total views: 2005
  • [From(publication date): 0-2018 - Dec 06, 2019]
  • Breakdown by view type
  • HTML page views: 1874
  • PDF downloads: 131
Top