alexa Taxane-Induced Neuropathic Pain: Current Evidence and Treating Strategies | OMICS International| Abstract
ISSN: 2167-0846

Journal of Pain & Relief
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  • Review Article   
  • J Pain Relief 2017, Vol 7(2): 311
  • DOI: 10.4172/2167-0846.1000311

Taxane-Induced Neuropathic Pain: Current Evidence and Treating Strategies

Vincenzo Pota1, Maria Beatrice Passavanti1, Pasquale Sansone1, Manlio Barbarisi2, Maria Caterina Pace1 and Caterina Aurilio1*
1Department of Women, Child, General and Specialistic Surgery, University of Campania “L. Vanvitelli”, , Napoli, Italy
2Institute of Neurosurgery, University of Cattolica, Rome, Italy
*Corresponding Author : Caterina Aurilio, Department of Women, Child, General and Specialistic Surgery, University of Campania “L. Vanvitelli”, Napoli, Italy, Tel: 00393664485084, Email: [email protected]

Received Date: Feb 26, 2018 / Accepted Date: Mar 06, 2018 / Published Date: Mar 22, 2018


Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling adverse event of most of commonly used antineoplastic agents. Previous studies have focused on several chemotherapeutic agents and reported that CIPN incidence varies from 19% to >85%. The mechanisms underlying CIPN are currently unknown. However, different theories have been proposed including microtubules dysfunction, mitochondrial dysfunction and mitochondrial toxicity, Glial pathway, substance P pathway, adenosine receptor pathway. CIPN is not simply to treat, and most randomized controlled trials failed to identify an effective therapy. Recent evidence supports the efficacy of serotonin (5-HT) and norepinephrine (NE) dual reuptake inhibitors (SNRI) in the treatment of neuropathy-related pain. Based on current evidence, we can speculate that duloxetine and topical menthol would improve CIPN pain as symptomatic treatment while, based on preclinical data, pifithrin-μ could be considered in future for the prevention of CIPN.

Keywords: Neuropathic cancer pain; Chemotherapy induced peripheral neuropathy; Microtubules

Citation: Pota V, Passavanti MB, Sansone P, Barbarisi M, Pace MC, et al. (2018) Taxane-Induced Neuropathic Pain: Current Evidence and Treating Strategies. J Pain Relief 7: 311. Doi: 10.4172/2167-0846.1000311

Copyright: © 2018 Pota V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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