E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Mini Review   
  • J Neuroinfect Dis ,
  • DOI: 10.4172/2314-7326.1000298

The Blood-Brain Barrier and Bioenergetics in Stroke

Emily Hone1, Sajad Sarvari2, Faezeh Moakedi3, Yuxin Liu4 and Xuefang Ren1,5,6*
1Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, USA
2Department of Basic Pharmaceutical Sciences, Rockefeller Neuroscience Institute, West Virginia University, USA
3Department of Biochemistry, Rockefeller Neuroscience Institute, West Virginia University, USA
4Department of Computer Science and Electrical Engineering, Rockefeller Neuroscience Institute, West Virginia University, USA
5Department of Microbiology, Immunology and Cell Biology, Rockefeller Neuroscience Institute, West Virginia University, USA
6Experimental Stroke Core, Center for Basic and Translational Stroke Research, Rockefeller Neuroscience Institute, West Virginia University, USA
*Corresponding Author : Xuefang Ren M.D., Ph.D, Department of Neuroscience, West Virginia University, 64 Medical Center Drive, Morgantown, WV26506, USA, Tel: (304)581-1892, Email: xuren@hsc.wvu.edu

Received Date: Jul 02, 2020 / Accepted Date: Jul 16, 2020 / Published Date: Jul 23, 2020

Abstract

Stroke is an overwhelming neurological disease with very limited treatment options. As blood-brain barrier (BBB) integrity is well-implicated in the prevention of brain injury, its regulation may prove beneficial for stroke patients. BBB cerebro-vascular endothelial cells primarily utilize mitochondria as their energy-producing source, and mitochondrial function has revealed importance in outcomes for tissue post-stroke. In this review, bioenergetics in relation to BBB permeability in stroke is discussed. Moreover, what causes mitochondrial dysfunction following stroke is explored.

Keywords: Blood brain barrier; BBB; Mitochondria; Bioenergetics; Stroke; Ischemia

Citation: Hone E, Sarvari S, Moakedi F, Liu Y, Ren X (2020) The Blood-Brain Barrier and Bioenergetics in Stroke. J Neuroinfect Dis 11: 298. Doi: 10.4172/2314-7326.1000298

Copyright: © 2020 Hone E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top