The Comparable Influence of Intrinsic and Extrinsic Factors on Esomeprazole Pharmacokinetics Following Intravenous and Oral Administration
Received Date: Aug 04, 2023 / Published Date: Aug 31, 2023
Abstract
This study aimed to assess the impact of intrinsic and extrinsic factors on the pharmacokinetics of esomeprazole, comparing its intravenous (IV) and oral administration routes. Esomeprazole, a proton pump inhibitor widely used for acid-related disorders, exhibits variable pharmacokinetic profiles due to individual variability and external factors. A randomized crossover design was employed, involving healthy participants receiving both IV and oral esomeprazole under different conditions. Blood samples were collected at predetermined intervals, and plasma concentrations were analyzed using advanced chromatographic methods. The results indicated that intrinsic factors such as age, gender, and genetic variations minimally affected esomeprazole pharmacokinetics, regardless of administration route. Similarly, extrinsic factors like diet, concomitant medications, and smoking showed consistent effects on both IV and oral administration. This suggests that the pharmacokinetic behavior of esomeprazole remains relatively consistent across administration routes and is robust against various factors. These findings contribute to a better understanding of esomeprazole's pharmacokinetic profile, supporting its clinical utility in diverse patient populations. Further research could explore specific mechanisms underlying these observations and their clinical implications.
Citation: Shalde H (2023) The Comparable Influence of Intrinsic and ExtrinsicFactors on Esomeprazole Pharmacokinetics Following Intravenous and OralAdministration. J Pharmacokinet Exp Ther 7: 193. Doi: 10.4172/jpet.1000193
Copyright: © 2023 Shalde H. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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