The Correlation between Genotype and Phenotype of Alzheimer's Disease
Received Date: Jan 01, 2018 / Accepted Date: Jan 15, 2018 / Published Date: Jan 22, 2018
Alzheimer’s disease (AD) is the most frequent cause of dementia, it manifests as a progressive decline in memory and other cognitive domains. The genetics of AD is complex and heterogeneous. Most cases are “sporadic late onset”, however, a small percentage of cases have an early onset and usually aggregate within families. Early studies revealed that a number of genes, including both rare mutations and common polymorphisms, play an important role in the development of AD. More recently it has been proposed that genetic variation may also explain some of the other features of clinical phenotype, such as age at onset, disease duration, cognitive decline, behavioral and psychiatric symptoms and so on. In this review, we compared the clinical phenotypes of reported mutations within the three causative genes and some common polymorphisms, with an emphasis on their heterogeneity. Hopefully, the unique phenotypic features of individual mutation will enable us to study molecular mechanisms, potentially explaining phenotypic differences and providing useful knowledge for the development of new therapeutic agents.
Keywords: Alzheimer’s disease; Genotype; Phenotype
Citation: Li HL, Jiang B, Wu ZY (2018) The Correlation between Genotype and Phenotype of Alzheimer’s Disease. A Retrospective Analysis in the Tajiri Project. J Alzheimers Dis Parkinsonism 8: 417. Doi: 10.4172/2161-0460.1000417
Copyright: ©2018 Li HL, et al. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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