alexa

GET THE APP

The Effect of Antiviral Agents in the Treatment of COVID-19 Patients: A Propensity Score-Matched and a Stabilized Inverted Probability of Treatment Weight Study (SIPTW)| Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • J Infect Dis Ther,
  • DOI: 10.4172/2332-0877.1000471

The Effect of Antiviral Agents in the Treatment of COVID-19 Patients: A Propensity Score-Matched and a Stabilized Inverted Probability of Treatment Weight Study (SIPTW)

Jamal Wadi Al Ramahi1*, Amal Matar2, Nour Hasan2, Ma’en Maher Al-Ali1, Lara Abdulhadi2, Dania Abu Kaf1, Hanadi Hamadalla3, Ala’a Bade4, Mohammad Atou5, Sae’ed Mar’i5, Tamer Alhame6, Obeidah Masoud7 and Hakan Erdem8
1Department of Medicine, The University of Jordan, Amman, Jordan
2Department of Clinical Pharmacy, Al Khalidi Hospital, Amman, Jordan
3Department of Pharmacy, Jordan Hospital, Amman, Jordan
4Department of Pharmacy, The Specialty Hospital, Amman, Jordan
5Department of Internal Medicine, The Specialty Hospital, Amman, Jordan
6Department of Nursing, The Specialty Hospital, Amman, Jordan
7Medical Department, Al Khalidi Hospital, Amman, Jordan
8Department Infectious Diseases and Clinical Microbiology, GATA Haydarpasa Training Hospital, Istanbul, Turkey
*Corresponding Author : Jamal Wadi Al Ramahi, Department of Medicine, The University of Jordan, Amman, Jordan, Email: [email protected]

Received Date: Jul 20, 2021 / Accepted Date: Aug 04, 2021 / Published Date: Aug 11, 2021

Abstract

Earlier purpose: To evaluate the antivirals casual effects in the treatment of COVID-19 patients, focusing on recovery, the need for home oxygen therapy on discharge and in-hospital mortality.

Methods: A retrospective study of the admitted COVID-19 patients, the outcomes assessed were effect-difference between antivirals and controls for recovery, mortality, and the need for home oxygen. A Propensity Score Matched-Patients (PSM), variables entered for patients were age, gender, documented fever, tobacco, body mass index, LDH level, ferritin level, antivirals, imaging severity categories, D-dimer level, oxygen saturation. Other variables were excluded for multicollinearity. Outcomes were inferred from the PSM-adjusted patients and Stabilized Inverse Probability of Treatment Weight (SIPTW) analysis.

Results: All cohort and PSM-adjusted patients were described. Mortality was for 143 (12.7%) patients in the ICU was 124 (55.8%). SIPTW analysis demonstrated no significant difference between the antiviral treatment arm and control patients in recovered (P=NS), the need for home oxygen therapy (P=NS), and the difference in all-cause mortality between the treatment and control groups (P=NS). On multivariate analysis, recovery, the need for home oxygen and mortality with both favipiravir and remdesivir was not significantly different.

Conclusion: There was no evidence of significant benefit from the antiviral therapy in the treatment of COVID-19 patients in recovery, home oxygen requirements, and death.

Keywords: Remdesivir; Favipiravir; COVID-19 mortality; Recovery; Home oxygen therapy

Citation: Al Ramahi JW, Matar A, Hasan N, Al-Ali MM, Abdulhadi L, et al. (2021) The Effect of Antiviral Agents in the Treatment of COVID-19 Patients: A Propensity Score-Matched and a Stabilized Inverted Probability of Treatment Weight Study (SIPTW). J Infect Dis Ther 9:471. Doi: 10.4172/2332-0877.1000471

Copyright: © Al Ramahi JW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Recommended Conferences
Article Usage
  • Total views: 257
  • [From(publication date): 0-0 - Dec 01, 2021]
  • Breakdown by view type
  • HTML page views: 136
  • PDF downloads: 121
Top