The Effect of Antiviral Agents in the Treatment of COVID-19 Patients: A Propensity Score-Matched and a Stabilized Inverted Probability of Treatment Weight Study (SIPTW)
Received Date: Jul 20, 2021 / Accepted Date: Aug 04, 2021 / Published Date: Aug 11, 2021
Abstract
Earlier purpose: To evaluate the antivirals casual effects in the treatment of COVID-19 patients, focusing on recovery, the need for home oxygen therapy on discharge and in-hospital mortality.
Methods: A retrospective study of the admitted COVID-19 patients, the outcomes assessed were effect-difference between antivirals and controls for recovery, mortality, and the need for home oxygen. A Propensity Score Matched-Patients (PSM), variables entered for patients were age, gender, documented fever, tobacco, body mass index, LDH level, ferritin level, antivirals, imaging severity categories, D-dimer level, oxygen saturation. Other variables were excluded for multicollinearity. Outcomes were inferred from the PSM-adjusted patients and Stabilized Inverse Probability of Treatment Weight (SIPTW) analysis.
Results: All cohort and PSM-adjusted patients were described. Mortality was for 143 (12.7%) patients in the ICU was 124 (55.8%). SIPTW analysis demonstrated no significant difference between the antiviral treatment arm and control patients in recovered (P=NS), the need for home oxygen therapy (P=NS), and the difference in all-cause mortality between the treatment and control groups (P=NS). On multivariate analysis, recovery, the need for home oxygen and mortality with both favipiravir and remdesivir was not significantly different.
Conclusion: There was no evidence of significant benefit from the antiviral therapy in the treatment of COVID-19 patients in recovery, home oxygen requirements, and death.
Keywords: Remdesivir; Favipiravir; COVID-19 mortality; Recovery; Home oxygen therapy
Citation: Al Ramahi JW, Matar A, Hasan N, Al-Ali MM, Abdulhadi L, et al. (2021) The Effect of Antiviral Agents in the Treatment of COVID-19 Patients: A Propensity Score-Matched and a Stabilized Inverted Probability of Treatment Weight Study (SIPTW). J Infect Dis Ther 9:471. Doi: 10.4172/2332-0877.1000471
Copyright: © Al Ramahi JW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Share This Article
Open Access Journals
Article Tools
Article Usage
- Total views: 1491
- [From(publication date): 0-2021 - Apr 25, 2024]
- Breakdown by view type
- HTML page views: 1058
- PDF downloads: 433
