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The Relationship between IL-6 and Nutritional Status in Patients with Gastrointestinal Tumors | OMICS International| Abstract

Journal of Oncology Research and Treatment
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  • Research Article   
  • J Oncol Res Treat 2019, Vol 4(1): 138

The Relationship between IL-6 and Nutritional Status in Patients with Gastrointestinal Tumors

Valéria Jósa1, Valentin Brodszky2, Zsombor Zrubka2, Attila Zaránd3, Tünde Mezei4, Zsuzsanna Szilasi5, Adrienne Fehér6, Iván Igaz7, Krisztián Somlai8, Keresztély Merkel9 and Zsolt Baranyai3*
1Department of Otorhinolaryngology and Head and Neck Surgery, Jahn Ferenc Hospital, Budapest, Hungary
2Department of Health Economics, Corvinus University of Budapest, Hungary
31st. Department of Surgery, Semmelweis University, Hungary
4Department of Urology, Jahn Ferenc Hospital, Budapest, Hungary
5Department of Otorhinolaryngology and Head and Neck Surgery, HDF Medical Centre, Budapest, Hungary
6Department of Laboratory Medicine, Semmelweis University, Hungary
7Department of Gastroenterology, Szent Imre Hospital, Hungary
8Department of Surgery, Szent Margit Hospital, Hungary
9Department of Surgery, Szent Imre Hospital, Budapest, Hungary
*Corresponding Author : Zsolt Baranyai, 1st Department of Surgery, Semmelweis University, Budapest, Hungary, Tel: +3630/4500-388, Email: [email protected]

Received Date: Feb 27, 2019 / Accepted Date: Mar 19, 2019 / Published Date: Mar 26, 2019

Abstract

Introduction: IL-6 is an essential factor in inflammatory processes; its level has been found to be elevated in a variety of gastrointestinal tumors. Nearly 30% of IL-6 circulating in the blood is produced by adipose tissue; however, there are no clear data on whether its level changes in obese patients.
Material and method: We studied 127 patients with gastrointestinal tumors of different stages. IL-6 levels, white blood cell count (WBC), and hemoglobin (Hgb) concentration were determined in preoperative blood samples. BMI was determined with a calibrated calculator, before surgery. During the statistical analysis of the data, correlation was calculated using Spearman, Wilcoxon, and Pearson correlation coefficients.
Results: In patients with various gastrointestinal tumors, the level of circulating IL-6 was unrelated to BMI. This result was not influenced by hemoglobin concentration, or by white blood cell count.
Conclusion: In gastrointestinal tumors, IL-6 production by adipose tissue is negligible as compared with cytokine expression by the tumor and its environment.

Keywords: BMI; Nutritional status; IL-6; Gastrointestinal tumor

Citation: Jósa V, Brodszky V, Zrubka Z, Zaránd A, Mezei T, et al. (2019) The Relationship between IL-6 and Nutritional Status in Patients with Gastrointestinal Tumors. J Oncol Res Treat 4: 138.

Copyright: © 2019 Jósa V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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