The Relationship between IL-6 and Nutritional Status in Patients with Gastrointestinal Tumors
Received Date: Feb 27, 2019 / Accepted Date: Mar 19, 2019 / Published Date: Mar 26, 2019
Introduction: IL-6 is an essential factor in inflammatory processes; its level has been found to be elevated in a variety of gastrointestinal tumors. Nearly 30% of IL-6 circulating in the blood is produced by adipose tissue; however, there are no clear data on whether its level changes in obese patients.
Material and method: We studied 127 patients with gastrointestinal tumors of different stages. IL-6 levels, white blood cell count (WBC), and hemoglobin (Hgb) concentration were determined in preoperative blood samples. BMI was determined with a calibrated calculator, before surgery. During the statistical analysis of the data, correlation was calculated using Spearman, Wilcoxon, and Pearson correlation coefficients.
Results: In patients with various gastrointestinal tumors, the level of circulating IL-6 was unrelated to BMI. This result was not influenced by hemoglobin concentration, or by white blood cell count.
Conclusion: In gastrointestinal tumors, IL-6 production by adipose tissue is negligible as compared with cytokine expression by the tumor and its environment.
Keywords: BMI; Nutritional status; IL-6; Gastrointestinal tumor
Citation: Jósa V, Brodszky V, Zrubka Z, Zaránd A, Mezei T, et al. (2019) The Relationship between IL-6 and Nutritional Status in Patients with Gastrointestinal Tumors. J Oncol Res Treat 4: 138.
Copyright: © 2019 Jósa V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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