The Role of miRNAs in Gastric Cancer
- *Corresponding Author:
- Guo-Hua Tang
Life Science Research Center
University of South China, Hengyang, P.R. China
E-mail: [email protected]
Received date: July 17, 2013; Accepted date: August 08, 2013; Published date: August 11, 2013
Citation: Tang GH, Tang M, Xie YJ (2013) The Role of miRNAs in Gastric Cancer. J Gastroint Dig Syst 3:129. doi: 10.4172/2161-069X.1000129
Copyright: © 2013 Tang GH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Despite promising developments of treatment, the mortality of gastric cancer remains high. MicroRNAs (miRNAs) are non-coding RNA molecules. There are extensive evidences that miRNAs play a dual role, as oncogenes or tumor suppressors through regulating cell proliferation, differentiation, and apoptosis. Additionally, some miRNAs, as promising diagnostic and prognostic biomarkers, are specifically related to gastric cancer. In the current review, we have summarized recent data concerning miRNAs in patient with gastric cancer, allowing us a better understanding miRNA as the prognostic and diagnostic biomarkers and the new targets for clinical therapeutic interventions for gastric cancer.