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Hindi Research Article
Oxidative Stress: A Comparison of Different Groups of Patients with Hepatitis-C in Hemodialysis Units
| Da Silva NMO1*, Kalb AC2, Vidales-Braz BM2, Dos Santo DM2, Zanella RC3, Martinez EP2 and Martinez AMB2 | |
| 1Institute Educar Brazil, Brazil | |
| 2Universidad Federal of Rio Grande, Brazil | |
| 3Hospital Pompéia, Brazil | |
| *Corresponding Author : | Da Silva NMO Institute Educar Brasil, Faculdade Dom Bosco, Brazil Tel: +55 53 3026-2099 E-mail: nayleoliveira@gmail.com |
| Received November 02, 2015; Accepted December 03, 2015; Published December 07, 2015 | |
| Citation: Da Silva NMO, Kalb AC, Vidales-Braz BM, Dos Santos DM, Zanella RC Martinez EP,Martinez AMB, et al. (2015) Oxidative Stress: A Comparison of Different Groups of Patients with Hepatitis-C in Hemodialysis Units. Kidney Disord Clin Pract 1: 104. doi:10.4172/kdc.1000104 | |
| Copyright: © 2015 Da Silva NMO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
There is a close relationship between patients undergoing hemodialysis (HD) treatment who are infected with hepatitis C virus (HCV) and oxidative stress (OS), which accelerates atherosclerotic processes and reduces the quality of life of the patients. Hemodialyzed patients have high morbidity and mortality. This study evaluated OS in patients undergoing HD against HCV infection. Four groups of patients (n=40 per group) were evaluated, including healthy patients (Group 1), patients on HD (Group 2), patients with HCV (Group 3) and patients with HCV on HD (Group 4). The groups were compared for the total antioxidant capacity (TAC) and the lipid peroxidation. The TAC decreased in the group 2 patients. In the analysis of the lipid peroxidation in erythrocytes, a significant increase (p<0.05) of the concentration of malondialdehyde (MDA) was observed in group 2 when compared to the group 3 patients. There was no significant difference (p>0.05) between the patients in groups 1, 3 and 4 and between group 2 when compared to group 4. The lipid peroxidation in the blood plasma demonstrates a significant association (p<0.05) in group 4. These results indicate that the HD process and HCV infection alter the peroxidation process by accelerating the process of atherosclerosis and reducing the quality of life of these patients.
