ISSN: 2573-4555

Journal of Traditional Medicine & Clinical Naturopathy
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  • Research Article   
  • J Tradit Med Clin Natur 2018, Vol 7(2): 272
  • DOI: 10.4172/2573-4555.1000272

Neuroprotective Potentials of Ayurvedic Rasayana Desmodium triquetrum on Brain Aging and Chemically Induced Amnesia in Animal Models Relevant to Dementia

Hanumanthachar Joshi*, Charan CS and Majed Abdo Alkanad
Department of Pharmacognosy and Phytochemistry, Sarada Vilas College of Pharmacy, , K. M. Puram, Mysore-570004, Karnataka, India
*Corresponding Author : Hanumanthachar Joshi, Department of Postgraduate Studies and Research, Mysore-570004, Karnataka, India, Tel: 9663373701, Email: amanjoshi17@yahoo.com

Received Date: Mar 02, 2018 / Accepted Date: Mar 21, 2018 / Published Date: Mar 26, 2018

Abstract

Cognitive impairments in dementia is a common feature which disrupts life style of the patients suffering neurodegenerative disorders. Management of cognitive dysfunctions such as dementia and Alzheimer’s disease is very challenging as there is proper medicine with proved effect is available at present. In the current study, neuroprotective potentials of methanol extract of dried roots of Desmodium triquetrum (DT) was investigated in the mouse models relevant to dementia. Exteroceptive behavioral models like Elevated plus maze and Morris water maze were used to assess learning and memory in mice. Scopolamine (0.4 mg/kg, i.p.) induced amnesia and diazepam (1 mg/kg, i.p.) amnesia were the interoceptive behavioral models. DT (50 and 100 mg/kg, p.o.) significantly attenuated amnesic deficits in scopolamine, diazepam and natural aging amnesic models. DT was also useful in reversing aging induced amnesia. DT increased whole brain acetyl cholinesterase inhibition activity in mice. Hence, DT might be used as memory enhancing agent and possibly may be employed in treatment of dementia and other neurodegenerative disorders. The mechanism of action may be due to its potential neuroprotective and acetyl cholinesterase inhibitory properties.

Keywords: Acetyl cholinesterase; Desmodium triquetrum; Dementia; Memory; Scopolamine

Citation: Joshi H, Charan CS, Alkanad MA (2018) Neuroprotective Potentials of Ayurvedic Rasayana Desmodium triquetrum on Brain Aging and Chemically Induced Amnesia in Animal Models Relevant to Dementia. J Tradit Med Clin Natur 7: 272. Doi: 10.4172/2573-4555.1000272

Copyright: © 2018 Joshi H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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