Wnt Signaling and Histological Characteristics of Odontogenic Tumors
Received Date: Dec 30, 2019 / Accepted Date: Jan 14, 2020 / Published Date: Jan 21, 2020
Abstract
We examined Notch signaling in oral tumors; most of our reported findings are based on immunohistochemical studies of Notch expression in odontogenic tumors. In our investigation, we suggested that Notch signaling is involved in cell differentiation and epithelial-mesenchymal interaction in odontogenic tumors. In addition, Jagged is strongly expressed as a ligand of Notch in odontogenic tumors, and Jagged-Notch signaling may play an important role in odontogenic tumorigenesis. Wnt is expressed during tooth development and may be involved in odontogenic tumor cell differentiation and epithelial-mesenchymal interaction. Interestingly, Wnt and Notch expression sites are similar in odontogenic tumors, suggesting that Notch and Wnt signals cooperatively affect tumor formation.
Keywords: Wnt; Notch; Ameloblastoma; Ameloblastic fibroma; Odontogenic myxoma
Citation: Nakano K, Takabatake K, Kawai H, Yoshida S, Maeda H, et al. (2020) Wnt Signaling and Histological Characteristics of Odontogenic Tumors. Diagn Pathol Open 5: 160. Doi: 10.4172/2476-2024.1000160
Copyright: © 2020 Nakano K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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