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He Studied Medicine at Manchester University (BSc (1st class Hons) in Medical Biochemistry, 1988, MB.ChB (with Hons), 1991). After junior hospital posts at Royal Preston Hospital (MRCP(UK) 1994), He returned to the University of Manchester to train in gastroenterology and to perform research with Prof J. Hickman and Prof C. Potten (Digestive Disorders Foundation and MRC Clinical Training Fellowships leading to PhD, 1999). During this time He studied the genetic regulation of apoptosis in the GI tract.
In 2000 he moved to the University of Liverpool as a clinical lecturer to complete my clinical training (2002). Following this he was awarded an Advanced Clinical Fellowship for Clinicians from the Wellcome Trust to study apoptosis in the stomach. he was appointed clinical senior lecturer in 2006, Professor in 2009 and Head of Department in 2010. he was awarded the ASNEMGE rising star award 2007 and the Sir Francis Avery Jones research medal from the British Society of Gastroenterology in 2008. he am also academic lead for Integrated Clinical Academic Training (ICAT) at the University of Liverpool.
The main focus of his research interest is studying factors which influence the pathogenesis of gastric and colorectal cancer and gastrointestinal neuroendocrine tumours. his research particularly focuses on the importance of apoptosis and of the gastrin family of peptides. Specific projects involve:
1. Understanding the genetic regulation of apoptosis in the stomach and intestine, particularly by members of the bcl-2 and NFkB families of proteins.
2. Importance of gastrin and Helicobacter infection during gastric carcinogenesis
3. Importance of the gastrin family of peptides in colorectal carcinogenesis
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