Drug Discovery and Bioinformatics of Marine Natural Products
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan
- *Corresponding Author:
- Hsueh-Wei Chang
Profressor of Department of Biomedical Science and Environmental Biology
Kaohsiung Medical University
E-mail: [email protected]
Received date: December 04, 2013; Accepted date: December 05, 2013; Published date: December 10, 2013
Citation: Chang HW (2013) Drug Discovery and Bioinformatics of Marine Natural Products. J Marine Sci Res Dev 4:e121. doi: 10.4172/2155-9910.1000e121
Copyright: © 2013 Chang HW. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Marine natural products covering 9% of biomedical compounds  have become a hot resource for drug discovery . Interestingly, different extractions of natural products may yield different cellular functions.For example, algaehave been reviewed  to be anti-cancer, anti-inflammation, and anti-oxidative stress. In the organic extracts of red algae (Gracilariatenuistipitata), it is cytotoxic to oral cancer Ca9-22 cell lines, such as methanol extract of G. tenuistipitata(MEGT)  and ethanol extract of G. tenuistipitata(EEGT) . Additionally, cultivation environment may also affect the bioactive metabolite content of marine algae .
In contrast, the aqueous extracts of G. tenuistipitata(AEGT) have some protective properties against cellular oxidative stress . For example, H2O2-induced plasmid DNA damages, growth retardation, cellular DNA damage, and cell cycle G2/M arrest in H1299 cells is recovered by AEGT. This result suggests that AEGT is a helpful antioxidant and may protect against oxidative stress-related cell damages.
For the contribution of bioinformatics, a marine natural product database had been constructed in 2002 . Adatabase of natural products and chemical entities from marine habitat has been reported  although it is unreachable currently. SuperNatural is a searchable database of natural compounds . Chem Spider (http://www. chemspider.com/)  is a comprehensive database of organic molecules from many different providers, including marine natural products database and others.Currently, the natural product domain seeker (NaPDoS) (http://www.biokepler.org/use_cases/napdos) is developed to provide the phylogeny information for studying secondary metabolite gene diversity . Therefore, the bioinformatics has gradually progressing to the field of marine natural products.
Furthermore, bioinformatics may also help to analyze pharmacogenomics study  in terms of SNP-SNP interaction [14-18] to predict the effectiveness of drugs and disease susceptibility. In future, the bioinformatics and pharmacogenomics studies may become more popular in marine natural products.
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