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I am currently a postdoc associate in Imperial College London since May 2016, working on transcriptional machinery involved in bacterial transcription initiation and activation. We apply single particle reconstruction method and determine complex structures which might elucidate bacterial transcription mechanism from structural perspective. Before that, I received my M.S degree in Sun Yat-sen University in China on June 2011, mostly focus on characterization and functional studies of marine viral genes that potentially involved in viral replication and infection. Afterwards I moved to Nanyang Technological University, Singapore and obtained my PhD degree in structural biology on February 2016 there. During my Ph.D study, I have characterized and determined several protein structures that involved in viral DNA replication, bacterial swarming, bacterial virulence regulation, or plant photosynthesis. Particularly, combining our structure and biochemical data, we revealed that how agrobacteria cross-talk to plant and reprogram virulence genes and switch off the infection machinery after successful infection.
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